Thylakoids reduce body fat and fat cell size by binding to dietary fat making it less available for absorption in high-fat fed mice
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- 作者：Karin G. Stenkula ; Eva-Lena Stenblom ; Caroline Montelius…
- 关键词：PPARγ ; PGC ; 1α ; FAS ; Adipose cell size ; Fatty liver disease
- 刊名：Nutrition & Metabolism
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：14
- 期：1
- 全文大小：1118KB
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Clinical Nutrition; Metabolic Diseases;
- 出版者：BioMed Central
- ISSN：1743-7075
- 卷排序：14
文摘
BackgroundDietary thylakoids derived from spinach have beneficial effects on body fat accumulation and blood lipids as demonstrated in humans and rodents. Important mechanisms established include delayed fat digestion in the intestine, without causing steatorrhea, and increased fatty acid oxidation in intestinal cells. The objective of our study was to elucidate if increased fecal fat excretion is an important mechanism to normalize adipose tissue metabolism during high-fat feeding in mice supplemented with thylakoids.