Substantia innominata: MR findings in Parkinson¡¯s disease

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• 作者：Hirobumi Oikawa ; Makoto Sasaki ; Shigeru Ehara and Takashi Abe
• 关键词：Substantia innominata ; Parkinsons disease ; Mini ; mental ; status examination ; Nucleus basalis of Meynert
• 刊名：Neuroradiology
• 出版年：2004
• 出版时间：October 2004
• 年：2004
• 卷：46
• 期：10
• 页码：817-821
• 全文大小：247 KB

文摘

To elucidate MR imaging changes of the substantia innominata in Parkinsons disease (PD), using a 1.5-T superconductive MR unit, the thickness of the substantia innominata was measured on coronal thin-section images in 44 PD patients and 20 age-matched control subjects. We also evaluated the correlation between the thickness of the substantia innominata and mental status in PD patients. Mean thickness of the substantia innominata was 2.3 mm in PD patients, and 2.5 mm in control subjects. Thinning of the substantia innominata was statistically significant in PD patients compared with control subjects, although there were large overlaps. Among the PD patients, thinning was remarkable in cases with dementia. A positive correlation between thickness of substantia innominata and score of Mini-Mental-Status-Examination was also observed in PD patients. Atrophy of the substantia innominata was demonstrated, especially in PD patients with cognitive impairment, on coronal MR images, and this is compatible with the previous pathological reports.