The 2G allele of promoter region of Matrix metalloproteinase-1 as an essential pre-condition for the early onset of oral squamous cell carcinoma

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• 作者：Rishiho Nishizawa (1)
  Masaki Nagata (2)
  Arhab A Noman (2)
  Nobutaka Kitamura (2)
  Hajime Fujita (2)
  Hideyuki Hoshina (2)
  Takehiko Kubota (3)
  Manami Itagaki (3)
  Susumu Shingaki (4)
  Makoto Ohnishi (5)
  Hiroshi Kurita (1)
  Kouji Katsura (6)
  Chikara Saito (4)
  Hiromasa Yoshie (3)
  Ritsuo Takagi (2)
  
• 刊名：BMC Cancer
• 出版年：2007
• 出版时间：December 2007
• 年：2007
• 卷：7
• 期：1
• 全文大小：566KB
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  41. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/7/187/prepub
  
• 作者单位：Rishiho Nishizawa (1)
  Masaki Nagata (2)
  Arhab A Noman (2)
  Nobutaka Kitamura (2)
  Hajime Fujita (2)
  Hideyuki Hoshina (2)
  Takehiko Kubota (3)
  Manami Itagaki (3)
  Susumu Shingaki (4)
  Makoto Ohnishi (5)
  Hiroshi Kurita (1)
  Kouji Katsura (6)
  Chikara Saito (4)
  Hiromasa Yoshie (3)
  Ritsuo Takagi (2)
  
  1. Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Asahi 3-1-1, 390-8621, Matsumoto, Japan
  2. Division of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Sciences, Gakkocho-dori 2-5274, 951-8514, Niigata, Japan
  3. Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Gakkocho-dori 2-5274, 951-8514, Niigata, Japan
  4. Division of Reconstructive Surgery for Oral and Maxillofacial Region, Niigata University Graduate School of Medical and Dental Sciences, Gakkocho-dori 2-5274, 951-8514, Niigata, Japan
  5. Division of Dental Clinic and Oral Surgery, Nagaoka Red Cross Hospital, Terashimamachi 297-1, 940-2085, Nagaoka, Japan
  6. Division of Oral and Maxillofacial Radiology, Niigata University Graduate School of Medical and Dental Sciences, Gakkocho-dori 2-5274, 951-8514, Niigata, Japan
  
• ISSN：1471-2407

文摘

Background Matrix metalloproteinase (MMP) is known to be involved in the initial and progressive stages of cancer development, and in the aggressive phenotypes of cancer. This study examines the association of single nucleotide polymorphisms in promoter regions of MMP-1 and MMP-3 with susceptibility to oral squamous cell carcinoma (OSCC). Methods We compared 170 Japanese OSCC cases and 164 healthy controls for genotypes of MMP-1 and MMP-3. Results The frequency of the MMP-1 2G allele was higher and that of the 1G homozygote was lower in the OSCC cases (p = 0.034). A multivariate logistic regression analysis revealed that subjects who were 45 years old or older had a significantly increased (2.47-fold) risk of OSCC (95%CI 1.47-.14, p = 0.0006), and those carrying the MMP-1 2G allele had a 2.30-fold risk (95%CI 1.15-.58, p = 0.018), indicating independent involvement of these factors in OSCC. One of the key discoveries of this research is the apparent reduction of the MMP-1 1G/1G and 1G/2G genotype distributions among the early onset OSCC cases under the ages of 45 years. It should be noted that the tongue was the primary site in 86.2% of these early onset cases. This could suggest the specific carcinogenic mechanisms, i.e. specific carcinogenic stimulations and/or genetic factors in the tongue. Conclusion Since the 2G allele is a majority of the MMP-1 genotype in the general population, it seems to act as a genetic pre-condition in OSCC development. However this report suggests a crucial impact of the MMP-1 2G allele in the early onset OSCC.