Autonomic nervous alterations associated with daily level of fatigue

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• 作者：Masaaki Tanaka (1)
  Kei Mizuno (2)
  Kouzi Yamaguti (3)
  Hirohiko Kuratsune (3)
  Akira Fujii (4)
  Hiromichi Baba (4)
  Kazuya Matsuda (4)
  Ayako Nishimae (5)
  Toshio Takesaka (5)
  Yasuyoshi Watanabe (1) (2)
  
• 关键词：Advanced trail making test ; 2 ; back Test ; Parasympathetic nerve function ; Selective attention ; Sympathetic nerve function
• 刊名：Behavioral and Brain Functions
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：7
• 期：1
• 全文大小：203KB
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• 作者单位：Masaaki Tanaka (1)
  Kei Mizuno (2)
  Kouzi Yamaguti (3)
  Hirohiko Kuratsune (3)
  Akira Fujii (4)
  Hiromichi Baba (4)
  Kazuya Matsuda (4)
  Ayako Nishimae (5)
  Toshio Takesaka (5)
  Yasuyoshi Watanabe (1) (2)
  
  1. Department of Physiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan
  2. Molecular Probe Dynamics Laboratory, RIKEN Center for Molecular Imaging Science, 6-7-3 Minatojima-minamimachi, Chuo-ku, Hyogo, 650-0047, Japan
  3. Department of Health Science, Faculty of Health Science for Welfare, Kansai University of Welfare Sciences, 3-11-1 Asahigaoka, Osaka, 582-0026, Japan
  4. Health Chemical Co., Ltd., 179 Ikeda, Kume, Tokoname City, Aichi, 479-0002, Japan
  5. Osaka Urban Industry Promotion Center, 1-4-5 Honmachi, Chuo-ku, Osaka City, Osaka, 541-0053, Japan
  
• ISSN：1744-9081

文摘

Background Fatigue is a common symptom in both sick and healthy people. We examined autonomic nervous alterations associated with fatigue to clarify the mechanisms underlying fatigue. Methods The study group consisted of 19 healthy participants who performed a 2-back test for 30 min as a fatigue-inducing mental task session. Before and after the session, they completed the advanced trail making test (ATMT) for 30 min for mental fatigue evaluation, subjective scales to measure fatigue sensation, and underwent electrocardiography to allow assessment of autonomic nerve activities. Results After the fatigue-inducing task, the total error counts on the ATMT tended to increase (P = 0.076); the ATMT for total trial counts (P = 0.001), the subjective level of fatigue (P < 0.001), and the % low-frequency power (%LF) (P = 0.035) increased significantly; and the % high-frequency power (%HF) decreased compared with before the fatigue-inducing task although this did not reach the statistical significance (P = 0.170). Although LF measured in absolute units did not change significantly before and after the fatigue-inducing task (P = 0.771), and HF measured in absolute units decreased after the task (P = 0.020). The %LF and LF/HF ratio were positively associated with the daily level of fatigue evaluated using Chalder's fatigue scale. In addition, %HF was negatively associated with the fatigue score. Conclusions Increased sympathetic activity and decreased parasympathetic activity may be characteristic features of both acute and daily levels of fatigue. Our findings provide new perspectives on the mechanisms underlying fatigue.