Association of Gankyrin and Stemness Factor Expression in Human Colorectal Cancer
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- 作者：Hiromasa Mine (1)
Toshiharu Sakurai (1)
Hiroshi Kashida (1)
Shigenaga Matsui (1)
Naoshi Nishida (1)
Tomoyuki Nagai (1)
Satoru Hagiwara (1)
Tomohiro Watanabe (2)
Masatoshi Kudo (1) - 关键词：Stem cell ; Nanog ; PSMD10 ; VEGF ; Colorectal adenoma
- 刊名：Digestive Diseases and Sciences
- 出版年：2013
- 出版时间：August 2013
- 年：2013
- 卷：58
- 期：8
- 页码：2337-2344
- 全文大小：1218KB
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Toshiharu Sakurai (1)
Hiroshi Kashida (1)
Shigenaga Matsui (1)
Naoshi Nishida (1)
Tomoyuki Nagai (1)
Satoru Hagiwara (1)
Tomohiro Watanabe (2)
Masatoshi Kudo (1)
1. Department of Gastroenterology and Hepatology, Kinki University, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan
2. Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan
文摘
Background It is widely accepted that the adenoma-carcinoma sequence represents the process by which most colorectal cancers (CRCs) arise. Although gankyrin is overexpressed in CRC tissues, its roles in the initiation step of colorectal carcinogenesis remain largely unexplored. Aim We investigated the expression of gankyrin and stemness factors in human colorectal adenomas, precancerous lesions, as well as CRC tissues to assess its involvement in colorectal carcinogenesis. Methods Expression of several molecules including gankyrin and certain stemness factors was compared in 50 pairs of adenoma and surrounding normal mucosa using real-time quantitative polymerase chain reaction and in 30 CRC tissues using immunohistochemistry. Results In CRC specimens, expression of CD133, a cancer stem cell marker, was significantly correlated with gankyrin expression. Gankyrin knockdown decreased the expression of vascular endothelial growth factor (VEGF) and stemness factors such as Nanog and Oct-4 in colorectal cancer cells. Expression of gankyrin and these stemness factors was significantly higher in adenomas than in the surrounding normal mucosa. Importantly, a significant correlation was observed between the expression of gankyrin, VEGF, and Nanog in colorectal adenomas. Conclusion In CRC development, gankyrin would control stem cell behavior by regulating the expression of stemness factors.