Application of polymeric nanoparticles prepared by an antisolvent diffusion with preferential solvation for iontophoretic transdermal drug delivery
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- 作者：Keishiro Tomoda (1) (2) (3)
Natsumi Yabuki (1)
Hiroshi Terada (1) (2) (3)
Kimiko Makino (1) (2) (3) - 关键词：PLGA ; Nanoparticle ; Transdermal ; Iontophoresis ; Antisolvent diffusion ; Indomethacin ; Preferential solvation
- 刊名：Colloid & Polymer Science
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：292
- 期：12
- 页码：3195-3203
- 全文大小：1,012 KB
- 参考文献：1. Prausnitz MR, Langer R (2008) Transdermal drug delivery. Nat Biotechnol 26(11):1261-268 CrossRef
2. Guy RH (1996) Current status and future prospects of transdermal drug delivery. Pharm Res 13(12):1765-769 CrossRef
3. Grossberg GT, Sadowsky C, Olin JT (2010) Rivastigmine transdermal system for the treatment of mild to moderate Alzheimer’s disease. Int J Clin Pract 64(5):651-60 CrossRef
4. Behl CR, Flynn GL, Kurihara T, Harper N, Smith W, Higuchi WI, Ho NFH, Pierson CL (1980) Hydration and percutaneous absorption: 1. Influence of hydration on alkanol permeation through hairless mouse skin. J Invest Dermatol 75:346-52 CrossRef
5. Williams AC, Barry BW (2004) Penetration enhancers. Adv Drug Deliv Rev 56(5):603-18 CrossRef
6. Wiechers JW, Zeeuw RA (1990) Transdermal drug delivery: efficacy and potential applications of the penetration enhancer Azone. Drug Des Deliv 6(2):87-00
7. Goodman M, Barry BW (1989) Lipid-protein-partitioning (LPP) theory of skin enhancer activity: finite dose technique. Int J Pharm 57(1):29-0 CrossRef
8. Ghafourian T, Zandasrar P, Hamishekar H, Nokhodchi A (2004) The effect of penetration enhancers on drug delivery through skin: a QSAR study. J Control Release 99:113-25 CrossRef
9. Naik A, Pechtold LAR, Potts RO, Guy RH (1995) Mechanism of oleic acid-induced skin penetration enhancement in vivo in humans. J Control Release 37(3):299-06 CrossRef
10. Drakulic BJ, Juranic IO, Eric S, Zloh M (2008) Role of complexes formation between drugs and penetration enhancers in transdermal delivery. Int J Pharm 363:40-9 CrossRef
11. Sapra B, Jain S, Tiwary AK (2008) Percutaneous permeation enhancement by terpenes: mechanistic view. AAPS J 10(1):120-32 CrossRef
12. Masada T, Higuchi WI, Srinivasan V, Rohr U, Fox J, Behl C, Pons S (1989) Examination of iontophoretic transport of ionic drugs across skin: baseline studies with the four-electrode system. Int J Pharm 49(1):57-2 CrossRef
13. Mudry B, Guy RH, Delgado-Charro MB (2006) Prediction of iontophoretic transport across the skin. J Control Release 111:362-67 CrossRef
14. Mudry B, Carrupt PA, Guy RH, Delgado-Charro MB (2007) Quantitative structure–permeation relationship for iontophoretic transport across the skin. J Control Release 122:165-72 CrossRef
15. Praunitz MR, Bose VG, Langer R, Weaver JC (1993) Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proc Natl Acad Sci U S A 90:10504-0508 CrossRef
16. Ueda H, Sugibayashi K, Morimoto Y (1995) Skin penetration-enhancing effect of drugs by phonophoresis. J Control Release 37:291-97 CrossRef
17. Henry S, McAllister DV, Allen MG, Prausnitz MR (1998) Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci 87(8):922-25 CrossRef
18. Bounoure F, Skiba ML, Besnard M, Arnaud P, Mallet E, Skiba M (2008) Effect of iontophoresis and penetration enhancers on transdermal absorption of metopimazine. J Dermatol Sci - 作者单位：Keishiro Tomoda (1) (2) (3)
Natsumi Yabuki (1)
Hiroshi Terada (1) (2) (3)
Kimiko Makino (1) (2) (3)
1. Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan
2. Center for Drug Delivery Research, Tokyo University of Science, Noda, Chiba, Japan
3. Center for Physical Pharmaceutics, Tokyo University of Science, Noda, Chiba, Japan - ISSN：1435-1536
文摘
Indomethacin-loaded poly(lactide-co-glycolide) (PLGA) nanoparticles with an average diameter of 100?nm were prepared by using a combination of an antisolvent diffusion method with preferential solvation (bare nanoparticles). Polyvinyl alcohol (PVA)-coated indomethacin-loaded PLGA nanoparticles with an average diameter of 100?nm were also prepared by emulsification and the solvent evaporation method (PVA-coated nanoparticles). Bare nanoparticles do not have a hydrophilic stabilizer on the surface; therefore, they have high hydrophobicity and negative charges. Electrophoretic mobility of bare nanoparticles at 5?mM NaCl solution was about 68 times higher than that of PVA-coated nanoparticles. Permeability of bare nanoparticles through rat skin was significantly higher than that of PVA-coated nanoparticles when iontophoresis was applied ex vivo. Indomethacin amount inside the skin after the permeation study by using bare nanoparticles was much higher than that by using PVA-coated nanoparticles. Indomethacin transition to circulation and accumulation in muscle by the transdermal delivery of indomethacin-loaded PLGA nanoparticles were significantly enhanced by using the combination of bare nanoparticles and iontophoresis in vivo. As for transdermal route of nanoparticles, both bare and PVA-coated nanoparticles were revealed to penetrate through the transfollicular pathway, and the migration of nanoparticles to follicles was enhanced by the application of iontophoresis. PLGA nanoparticles prepared by the antisolvent diffusion with preferential solvation are beneficial for iontophoretic transdermal delivery of therapeutic agents.