Immunohistochemical actinin-4 expression in infiltrating gliomas: association with WHO grade and differentiation

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• 作者：Shintaro Fukushima (1) (2)
  Akihiko Yoshida (1)
  Kazufumi Honda (3)
  Akiko Miyagi Maeshima (1)
  Yoshitaka Narita (4)
  Tesshi Yamada (3)
  Soichiro Shibui (4)
  Hitoshi Tsuda (1)
  
• 关键词：Actinin ; 4 ; Immunohistochemistry ; Infiltrating glioma ; WHO grade ; Differentiation
• 刊名：Brain Tumor Pathology
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：31
• 期：1
• 页码：11-16
• 全文大小：664 KB
• 作者单位：Shintaro Fukushima (1) (2)
  Akihiko Yoshida (1)
  Kazufumi Honda (3)
  Akiko Miyagi Maeshima (1)
  Yoshitaka Narita (4)
  Tesshi Yamada (3)
  Soichiro Shibui (4)
  Hitoshi Tsuda (1)
  
  1. Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan
  2. Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan
  3. Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
  4. Department of Neurosurgery and Neuro-oncology, National Cancer Center Hospital, Tokyo, Japan
  
• ISSN：1861-387X

文摘

Actinin-4 is an isoform of nonmuscular α-actinin and actin-bundling protein that plays an important role in cancer invasion and metastasis by enhancing cellular motility. Recent studies have revealed an association between several clinicopathological profiles and actinin-4 overexpression in human cancers. In this study, we investigated the immunohistochemical actinin-4 expression in 39 infiltrating gliomas. The specimens included three diffuse astrocytomas, three oligodendrogliomas, one oligoastrocytoma, two anaplastic astrocytomas, four anaplastic oligodendrogliomas, three anaplastic oligoastrocytomas, 17 glioblastomas, four gliosarcomas, and two glioblastomas with oligodendroglial component. All seven World Health Organization (WHO) grade II tumors were negative for actinin-4, whereas 20 of 22 tumors with strong actinin-4 expression were WHO grade IV. Actinin-4 expression was significantly associated with histological grade (P?<?0.0001) and proliferative activity measured by Ki-67 staining (P?=?0.0045). Notably, actinin-4 expression was more pronounced in high-grade astrocytic tumors than oligodendroglial tumors (P?<?0.0001). Additionally, pseudopalisading cells in glioblastoma exhibited stronger actinin-4 expression than the rest, likely reflecting enhanced cellular motility in pseudopalisades. This study is the first to demonstrate significant correlation between actinin-4 expression and tumor grade using clinical glioma samples. Although diagnostic utility of this marker awaits future exploration, actinin-4 may help distinguish between astrocytic and oligodendroglial lines of differentiation.