Genome-wide amplification of proviral sequences reveals new polymorphic HERV-K(HML-2) proviruses in humans and chimpanzees that are absent from genome assemblies
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- 作者：Catriona M Macfarlane ; Richard M Badge
- 关键词：Endogenous retrovirus ; HERV ; K ; HML ; 2 ; Provirus ; Human genome
- 刊名：Retrovirology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：12
- 期：1
- 全文大小：1,372 KB
- 刊物主题：Virology; Infectious Diseases; Cancer Research;
- 出版者：BioMed Central
- ISSN：1742-4690
文摘
Background To date, the human population census of proviruses of the Betaretrovirus–like human endogenous retroviral (HERV-K) (HML-2) family has been compiled from a limited number of complete genomes, making it certain that rare polymorphic loci are under-represented and are yet to be described.