The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility

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• 作者：Tim J. van den Broek ; Bas H. A. Kremer ; Marisa Marcondes Rezende…
• 关键词：Metabolic challenge test ; Vitamins ; Carotenoids ; Phenotypic flexibility ; Inflammation ; Systems biology ; Lipid ; Glucose
• 刊名：Genes & Nutrition
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：12
• 期：1
• 全文大小：1272KB
• 刊物主题：Human Genetics; Clinical Nutrition; Gene Function; Biomedicine, general;
• 出版者：BioMed Central
• ISSN：1865-3499
• 卷排序：12

文摘

BackgroundVitamins and carotenoids are key micronutrients facilitating the maintenance of health, as evidenced by the increased risk of disease with low intake. Optimal phenotypic flexibility, i.e., the ability to respond to a physiological challenge, is an essential indicator of health status. Therefore, health can be measured by applying a challenge test and monitoring the response of relevant phenotypic processes. In this study, we assessed the correlation of three fat-soluble vitamins, (i.e., vitamin A or retinol, vitamin D₃, two homologues of vitamin E) and four carotenoids (i.e., α-carotene, β-carotene, β-cryptoxanthin, and lycopene), with characteristics of metabolic and inflammatory parameters at baseline and in response to a nutritional challenge test (NCT) in a group of 36 overweight and obese male subjects, using proteomics and metabolomics platforms. The phenotypic flexibility concept implies that health can be measured by the ability to adapt to a NCT, which may offer a more sensitive way to assess changes in health status of healthy subjects.