Effectiveness of retigabine against levobupivacaine-induced central nervous system toxicity: a prospective, randomized animal study

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• 作者：Yanxin Cheng ; Hong Li ; Jun Li ; Yongxue Chen ; Ran Duan ; Jinge Yuan…
• 关键词：KCNQ2/3 channels ; Retigabine ; Seizure ; Local anesthetic toxicity
• 刊名：Journal of Anesthesia
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：30
• 期：1
• 页码：109-115
• 全文大小：2,370 KB
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• 作者单位：Yanxin Cheng (1)
  Hong Li (2)
  Jun Li (3)
  Yongxue Chen (4)
  Ran Duan (1)
  Jinge Yuan (4)
  Senming Zhao (1)
  
  1. Pain Medicine Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
  2. Department of Anesthesiology, The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, China
  3. Department of Anesthesiology, Kailuan General Hospital, Tangshan, Hebei, China
  4. Department of Anesthesiology, Handan Center Hospital, Handan, Hebei, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Anesthesiology
  
• 出版者：Springer Japan
• ISSN：1438-8359

文摘

Purpose KCNQ2/3 channels play an important role in controlling neuronal excitability. Agents that decrease KCNQ2/3 current amplitudes are proconvulsant, whereas KCNQ2/3 current enhancers are anticonvulsant. Levobupivacaine is able to block the KCNQ2/3 channels and enhance neuronal excitation, whereas retigabine is able to reopen the channels and thus reduce overexcitation of neurons. In this study, we aimed to determine if retigabine is able to abolish local-anesthetic-induced seizures.