文摘
Herein we report a facile surfactant-free two-step method to prepare hydroxypropyl methylcellulose/poly(acrylic acid) (HPMC/PAA) hybrid nanogels. The HPMC/poly(N,N-methylenebisacrylamide) (PMBA) nanoparticles were firstly prepared by free radical polymerization of N,N-methylenebisacrylamide (MBA) in HPMC aqueous solution. In the second step, HPMC/PAA nanogels were synthesized by polymerization using the as-prepared HPMC/PMBA nanoparticles as the seeds and acrylic acid (AA) and MBA as the monomer and cross-linker, respectively. Dynamic light scattering (DLS) experiments indicated the nanogels were monodispersed with the nanogel sizes ranging from 95 to 310?nm and the polydispersity index (PDI) values ranging from 0.043 to 0.122. Transmission electron microscope (TEM) experiments demonstrated that nanogels have a core/shell structure. Furthermore, the monodisperse nanogels have a good temperature and pH sensibility, and the nanogel diameter was decreased with increasing temperature while increased with rising pH. This method provides a new way of preparation of monodisperse polymer nanogels with a core/shell structure.