Astrocyte elevated gene-1 is a novel biomarker of epithelial–mesenchymal transition and progression of hepatocellular carcinoma in two China regions

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• 作者：Jiasheng Zheng (1) (2)
  Cong Li (1) (2)
  Xia Wu (3)
  Yingzhuo Yang (3)
  Meijun Hao (1) (2)
  Shoupeng Sheng (1) (2)
  Yu Sun (1) (2)
  Honghai Zhang (1) (2)
  Jiang Long (1) (2)
  Caixia Hu (1) (2)
  
• 关键词：Hepatocellular carcinoma ; Astrocyte elevated gene ; 1 (AEG ; 1) ; Vimentin ; Epithelial–mesenchymal transition (EMT) ; Biomarker
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：35
• 期：3
• 页码：2265-2269
• 全文大小：134 KB
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• 作者单位：Jiasheng Zheng (1) (2)
  Cong Li (1) (2)
  Xia Wu (3)
  Yingzhuo Yang (3)
  Meijun Hao (1) (2)
  Shoupeng Sheng (1) (2)
  Yu Sun (1) (2)
  Honghai Zhang (1) (2)
  Jiang Long (1) (2)
  Caixia Hu (1) (2)
  
  1. Intervention Therapy Center of Liver Diseases, Beijing You’an Hospital, Capital Medical University, Beijing, 100069, China
  2. Beijing Institute of Liver Diseases, Beijing You’an Hospital, Capital Medical University, Beijing, 100069, China
  3. Department of Infectious Disease, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China
  
• ISSN：1423-0380

文摘

Astrocyte elevated gene-1 (AEG-1) is involved in important biological processes including cell invasion, metastasis, and carcinogenesis. However, its clinical significance has remained largely unknown in hepatocellular carcinoma. Here, specimens from 144 patients with hepatocellular carcinomas in Beijing and Heilongjiang regions were investigated by immunohistochemical staining for AEG-1, vimentin, and E-cadherin expressions. A clinicopathological study revealed that AEG-1 expression level in tumor cells was significantly correlated with TNM stage (P--.001) and Edmonson grade (P-lt;-.0001). In addition, AEG-1, vimentin, and E-cadherin (epithelial–mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that AEG-1 may be an epithelial–mesenchymal transition-associated biomarker in human hepatocellular carcinoma and play important roles in the progression of hepatocellular carcinoma. In addition, the AEG-1 gene is a potential target for elimination of hepatocellular carcinoma in the future.