Ovarian masses in children and adolescents in China: analysis of 203 cases

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• 作者：Hongqian Liu (1) (2) (3) (4)
  Xiangao Wang (5)
  Donghao Lu (1) (6)
  Zhihong Liu (1) (4)
  Gang Shi (1) (4)
  
• 关键词：Ovarian mass ; Pediatric ; Germ cell ; Epithelial tumor ; Laparoscope
• 刊名：Journal of Ovarian Research
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：6
• 期：1
• 全文大小：325KB
• 参考文献：1. Hassan E, Creatsas G, Deligeorolgou E, / et al.: lus-plus">Ovarian tumors during childhood and adolescence. A clinicopathological study. / Eur J Gynaecol Oncol 1999, lus-plus">20:124.
  2. Piver MS, Patton T: lus-plus">Ovarian cancer in children. / Semin Surg Oncol 1986, lus-plus">2:163. CrossRef
  3. Deligeoroglou E, Eleftheriades M, Shiadoes V, / et al.: lus-plus">Ovarian masses during adolescence: clinical, ultrasonographic and pathological findings, serum tumor markers, and endocrinological profile. / Gynaecol Endocrinol 2004, lus-plus">19:1-. CrossRef
  4. Quint EH, Smith YR: lus-plus">Ovarian surgery in premenarchal girls. / J Pediatr Adolesc Gynecol 1999, lus-plus">12:27. CrossRef
  5. Mayer C, Miller DM, Ehlen TG: lus-plus">Peritoneal implantation of squamous cell carcinoma following rupture of a dermoidcyst during laparoscopic removal. / Gynaecol Oncol 2002, lus-plus">84:180-83. CrossRef
  6. Kathleen FB, Michael CC, Leonidas GK, / et al.: lus-plus">A population-based analysis of 1037 malignant ovarian tumors in the pediatric population. / J Surg Res 2009, lus-plus">156:45-9. CrossRef
  7. Morowitz M, Huff D, Von Allmen D: lus-plus">Epithelial ovarian tumors in children: a retrospective analysis. / J Pediatr Surg 2003, lus-plus">38:331-35. CrossRef
  8. JUNAID TA: lus-plus">Ovarian neoplasms in children and adolescents in Ibadan, Nigeria. / Cancer 1981, lus-plus">47:610-14. CrossRef
  9. McCarthy J, Erickson K, Smith Y, / et al.: lus-plus">Premenarchal ovarian torsion and elevated CA-125. / J Pediatr Adolesc Gynecol 2009, lus-plus">23:47-0. CrossRef
  10. Rousseau V, Massicot R, Darwish AA, / et al.: lus-plus">Emergency management and conservative surgery of ovarian torsion in children: a report of 40 cases. / J Pediatr Adolesc Gynecol 2008, lus-plus">21:201-06. CrossRef
  11. Anish AS, Creighton EL, Thomas MP: lus-plus">Early polycystic ovary syndrome as a possible etiology of unexplained premenarcheal ovarian torsion. / J Pediatr Adolesc Gynecol 2009, lus-plus">22:265-69. CrossRef
  12. Mayer JP, Bettolli M, Kolberg-Schwerdt A, / et al.: lus-plus">Laparoscopic approach to ovarian mass in children and adolescents: already a standard in therapy. / J Laparoendosc Adv Surg Tech A 2009, lus-plus">19:s111-s115. CrossRef
  13. Ates O, Karakaya E, Hakgüder G, / et al.: lus-plus">Laparoscopic excision of a giant ovarian cyst after ultrasound guided drainage. / J Pediatr Surg 2006, lus-plus">41:E9-E11. CrossRef
  14. Deprest J, Moerman P, Corneillie P, / et al.: lus-plus">Ovarian borderline mucinous tumor in a premenarchal girl: Review on ovarian epithelial cancer in young girls. / Gynecol Oncol 1992, lus-plus">45:219. CrossRef
  
• 作者单位：Hongqian Liu (1) (2) (3) (4)
  Xiangao Wang (5)
  Donghao Lu (1) (6)
  Zhihong Liu (1) (4)
  Gang Shi (1) (4)
  
  1. Department of Obstetric and Gynecologic, West China Second University Hospital, Sichuan University, Chengdu, 610041, China
  2. Laboratory of Cell and Gene Therapy, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, 610041, China
  3. Laboratory of Genetics, West China Institute of Women and Children’s Health, Sichuan University, West China Second University Hospital, Chengdu, 610041, China
  4. Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu, 610041, China
  5. Department of Diagnostic Imaging, Affiliated Hospital of Zunyi Medical Collage, 201 Dalian Road, Zunyi, Guizhou, 563003, China
  6. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden
  

文摘

Objective The true incidence of ovarian tumors in children is unknown. Few studies beyond case reports and case series have been published concerning pediatric ovarian tumors. Herein we review a large number of ovarian tumor cases. Methods The charts of 203 patients who presented with adnexal masses were reviewed. Results The patient’s ranged in age from 2 to 18?years (mean--5.6?years), with 30 being premenarchal (14.8%). The incidence of ovarian tumor increases with age, especially in patients older than 14?years. The main complaint was abdominal pain or abdominal distension in 117 patients (57.7%). A high AFP level in a pre-pubic girl with an adnexal mass is indicative of a malignant ovarian tumor. The 214 adnexal masses (11 patients had bilateral cysts) consisted of benign tumorous oophoropathy (107 masses, 50.0%), borderline and malignant tumors (29 masses, 13.6%), and nontumorous oophoropathy (78 masses, 36.5%). Of the 136 neoplasia, germ cell tumors accounted for 71.5%. Surgical intervention was performed in 98.5% of cases. There were statistically decreased blood loss, surgery duration and days of hospitalization with the laparoscopic procedure when compared with open surgery. Conclusions Abdominal pain is the most common complaint in young patients with adnexal masses. AFP is the most useful diagnostic biomarker of ovarian tumors in young females. Laparoscopic resection of ovarian cysts is an alternative operation approach.