Development of Long-Circulating pH-Sensitive Liposomes to Circumvent Gemcitabine Resistance in Pancreatic Cancer Cells

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• 作者：Hongtao Xu ; James W. Paxton ; Zimei Wu
• 刊名：Pharmaceutical Research
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：33
• 期：7
• 页码：1628-1637
• 全文大小：893 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Pharmacy
  Biochemistry
  Medical Law
  Biomedical Engineering
  
• 出版者：Springer Netherlands
• ISSN：1573-904X
• 卷排序：33

文摘

PurposesTo develop pH-sensitive liposomes (PSL) containing a high content of gemcitabine; and to investigate whether drug loading (DL) would alter the in vitro and pharmacokinetic properties.