Polymethacrylate microparticles covalently functionalized with an ionic liquid for solid-phase extraction of fluoroquinolone antibiotics

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• 作者：Ruiling Wang ; Yanan Yuan ; Xun Yang ; Yehong Han ; Hongyuan Yan
• 关键词：Ionic liquid functionalized microparticles ; Solid ; phase extraction ; Urine sample ; Fluoroquinolones
• 刊名：Microchimica Acta
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：182
• 期：13-14
• 页码：2201-2208
• 全文大小：1,132 KB
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  21.Tang Q, Yang
• 作者单位：Ruiling Wang (1) (2)
  Yanan Yuan (1)
  Xun Yang (1)
  Yehong Han (1)
  Hongyuan Yan (1) (3)
  
  1. Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Hebei University, Baoding, 071002, China
  2. Department of Pharmacy, Shijiazhuang Maternal and Child Health Hospital, Shijiazhuang, 050080, China
  3. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding, 071002, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Inorganic Chemistry
  Physical Chemistry
  Characterization and Evaluation Materials
  Monitoring, Environmental Analysis and Environmental Ecotoxicology
  
• 出版者：Springer Wien
• ISSN：1436-5073

文摘

Microparticles were synthesized by suspension copolymerization of the synthetic ionic liquid (IL) 1-allyl-3-methyl-imidazolium bromide with ethylene glycol dimethacrylate. The particles have a regular spherical shape and an average diameter of 65?±-4 μm. Their affinity for the fluoroquinolone antibiotics ofloxacin (OFL), lomefloxacin (LOM) and ciprofloxacin (CIP) is much higher than that of the blank polymer (not containing an IL), of polymers using methacrylic acid as functional monomer, of hydrophilic-lipophilic balanced sorbents, and of C₁₈ sorbents. The microparticles were applied to the solid-phase extraction and rapid preconcentration of the fluoroquinolones from urine which then were quantified by HPLC. The calibration plot covers the 0.05 to 20 μg mL? concentration range, and the average recoveries at three spiking levels range from 93.6 to 103.7 %, with RSD of ?.7 %. The method was successfully applied to the determination of fluoroquinolones in spiked urine.