Functional promoter -31G/C variant of Survivin gene predict prostate cancer susceptibility among Chinese: a case control study

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• 作者：Jiawei Chen (1)
  Xinhai Cui (2)
  Hai Zhou (1)
  Chao Qin (1)
  Qiang Cao (1)
  Xiaobing Ju (1)
  Pu Li (1)
  Hongzhou Cai (1)
  Jian Zhu (1)
  Xiaoxin Meng (1)
  Meilin Wang (3)
  Zhengdong Zhang (3)
  Pengfei Shao (1)
  Jie Li (1)
  Changjun Yin (1)
  
• 关键词：Prostate cancer ; Genetic variation ; Survivin ; Apoptosis
• 刊名：BMC Cancer
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：13
• 期：1
• 全文大小：198KB
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  53. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/13/356/prepub
  
• 作者单位：Jiawei Chen (1)
  Xinhai Cui (2)
  Hai Zhou (1)
  Chao Qin (1)
  Qiang Cao (1)
  Xiaobing Ju (1)
  Pu Li (1)
  Hongzhou Cai (1)
  Jian Zhu (1)
  Xiaoxin Meng (1)
  Meilin Wang (3)
  Zhengdong Zhang (3)
  Pengfei Shao (1)
  Jie Li (1)
  Changjun Yin (1)
  
  1. State Key Laboratory of Reproductive Medicine, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 300 Guangzhou Road, Nanjing, 210029, China
  2. Department of Pediatric surgery, Qiluhospital Shandong University, Jinan, China
  3. Department of Molecular and Genetic Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China
  
• ISSN：1471-2407

文摘

Background Abnormal expression of Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5, also called as survivin), a novel member of the inhibitor of apoptosis protein (IAP) family, has implications in many types of cancer and is considered as a new therapeutic target. We suppose that genetic variant rs9904341 in the 5-UTR region of survivin gene may be associated with the development and progression of prostate cancer (PCa) in Chinese population. Methods TaqMan assay method was used to genotype the polymorphism in the hospital-based case–control analysis of 665 patients with PCa and 710 age-matched cancer-free controls. The genetic associations with the occurrence and progression of PCa were calculated by logistic regression. Results Our results indicated that compared with GG genotypes, there was a statistically significant increased risk of PCa associated with those with CC genotypes [odds ratios (ORs)--.57, 95%confidence intervals (CIs)--.17-2.13, P--.004]. Moreover, stratification analysis revealed that the association was more pronounced in subgroups of nondrinkers, nonsmokers and those without a family history of cancer (all P-lt;-.05). In addition, we observed that PSA?≥-0 was more frequent in patients carrying GC/CC genotypes than in those with a wild type genotype. Conclusion The functional survivin rs9904341 genetic variant may have a substantial influence on the PCa susceptibility and evolution.