Matrix Metalloproteinase-1 (MMP1) Polymorphism is Associated with Lowered Risk of Nasopharyngeal Carcinoma in Asian Population

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• 作者：Zhen Li ; Hongzhou Ge ; Yong-Gang Xie ; Guang-Ying Xie…
• 关键词：Matrix metalloproteinase ; 1 ; Polymorphism ; Nasopharyngeal carcinoma
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：71
• 期：2
• 页码：999-1004
• 全文大小：422 KB
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• 刊物主题：Biochemistry, general; Pharmacology/Toxicology; Biotechnology; Cell Biology; Biophysics and Biological Physics;
• 出版者：Springer US
• ISSN：1559-0283

文摘

Data on the association between ?607 1G?>?2G polymorphism in the promoter region of matrix metalloproteinase-1 (MMP1) and nasopharyngeal carcinoma (NPC) are conflicting. The aim of this study was to confirm whether this polymorphism was a causative factor of NPC. We searched PubMed, Embase, and China National Knowledge Infrastructure (CNKI) for studies on the present topic. A total of four publications (1,044 NPC patients and 1,284 healthy control subjects) were included and meta-analysis was performed to assess the association between ?607 1G?>?2G polymorphism and NPC risk. Odds ratio (OR) with 95?% confidence interval (95?% CI) was calculated for 1G1G versus 2G2G, 1G1G?+?1G2G versus 2G2G, 1G1G versus 1G2G?+?2G2G, 1G versus 2G, and 1G2G versus 2G2G contrast models. Meta-analysis results showed significantly reduced risk of NPC associated with the 1G1G versus 2G2G, 1G versus 2G and 1G2G versus 2G2G contrast models (OR?=?0.61, 95?% CI 0.49-.77; OR?=?0.78, 95?% CI 0.65-.92; OR?=?0.86, 95?% CI 0.74-.99, respectively). When we continued to perform subgroup analysis by ethnicity, the significant association persisted in Asian population and was most pronounced under the 1G2G versus 2G2G model (OR?=?0.85, 95?% CI 0.73-.99). These data suggested that MMP1 ?607 1G?>?2G polymorphism was associated with reduced risk of NPC, particularly in the population of Asian descent.