Trade off situation between thymus and growth hormone: age-related decline of growth hormone is a cause of thymic involution but favorable for elongation of lifespan

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• 作者：Katsuiku Hirokawa ; Masanori Utsuyama ; Yuko Kikuchi
• 关键词：Thymus ; Growth hormone ; Immune system ; IgF ; 1 ; Lifespan ; Hypopituitary dwarf mice ; Transgenic mice
• 刊名：Biogerontology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：17
• 期：1
• 页码：55-59
• 全文大小：332 KB
• 参考文献：Bartke A, Chandrashekar V, Turyn D, Steger RW, Debeljuk L, Winters TA, Mattison JA, Danilovich NA, Croson V, Wernsing DR, Kopchick JJ (1999) Effect of growth hormone overexpression and growth hormone resistance on neuroendocrine and reproductive functions in transgenic and knock-out mice. Proc Soc Exp Biol Med 222:113–123CrossRef PubMed
  Benencia F, Harshman S, Duran-Oritz S, Lubbers ER, List EO, Householder L, Alnaeeli M, Liang X, Welch L, Kopchick JJ, DE Berryman (2014) Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations. Endocrinology 18:en20141794
  Chidgey A (2008) Effects of growth hormone in enhancing thymic regrowth and T-cell reconstitution. Expert Rev Clin Immunol 4(4):433–439CrossRef PubMed
  Cross RJ, Bryson JS, Roszman TL (1992) Immunological disparity in the hypopituitary dwarf mouse. J Immunol 148:1347–1352PubMed
  Dialynas E, Brown-Borg H, Bartke A (1999) Immune function in transgenic mice overexpressing growth hormone (GH) releasing hormone, GH or GH antagonist. Proc Soc Exp Biol Med 221:178–183CrossRef PubMed
  Dooley J, Liston A (2012) Molecular control over thymic involution: from cytokine and microRNA to aging and adipose tissue. Eur J Immunol 42:1073–1079CrossRef PubMed
  Duquesnoy RJ (1972) Immunodeficiency of the thymus-depending system of the Ames dwarf mouse. J Immunol 108:1578–1590PubMed
  Fabris N, Pierpoali W, Sorkin E (1971) Hormone and immunological capacity. 3. The immunodeficiency diseases of hypopituitary Snell Bagg dwarf mice. Clin Exp Immunol 9:209–225PubMedCentral PubMed
  Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Cheng C-H, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD (2011) Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer and diabetes in humans. Sci Transl Med 16:1–9
  Haneji N, Hamano H, Yagita K, Hayashi Y (1994) A new model for primary Sjögren’s syndrome in NFS/sld mutant mice. J Immunol 153:2769–2777PubMed
  Hayashi Y, Sato M, Hirokawa K (1985) Induction of experimental allergic sialadenitis in mice. Am J Pathol 118:476–483PubMedCentral PubMed
  Herasimtschuk AA, Hansen BR, Langkilde A, Moyle GJ, Andersen O, Imami N (2013) Low-dose growth hormone for 40 weeks induces HIV-1-specific T cell responses in patients on effective combination anti-retroviral therapy. Clin Exp Immunol 173(3):444–453PubMedCentral CrossRef PubMed
  Hirokawa K, Makinodan T (1975) Thymic involution: effect on T cell differentiation. J Immunol 114:1659–1664PubMed
  Hirokawa K, Sado T (1976) Early decline of thymic effect on T cell differentiation. Mech Ageing Dev 7:89–95CrossRef
  Hirokawa K, Sato K, Makinodan T (1982) Influence of age of thymic grafts on the differentiation of T cells in nude mice. Clin Immunol Immunopathol 24:251–262CrossRef PubMed
  Hirokawa K, Utsuyama M, Katsura Y, Sado T (1988) Influence of age on the proliferation and peripheralization of thymic T cells. Arch Pathol Lab Med 112:13–21PubMed
  Hirokawa K, Utsuyama M, Kobayashi S (1998) Hypothalamic control of development and aging of the thymus. Mech Ageing Dev 100:177–185CrossRef PubMed
  Hirokawa K, Utsuyama M, Kobayashi S (2001) Hypothalamic control of thymic function. Cell Mol Biol 47:97–102PubMed
  Lynch HE, Goldberg GL, Chidgey A, van den Brink MR, Boyd R, Sempowski GD (2009) Thymic involution and immune reconstitution. Trends Immunol 30:366–373PubMedCentral CrossRef PubMed
  Mackall CL, Fleisher TA, Brown MR, Andrich MP, Chen CC, Feuerstein IM, Horowitz ME, Magrath IT, Shad AT, Steinberg SM, Wexler LH, Gress RE (1995) Age, thymopoiesis, and CD4+ T lymphocytes regeneration after intensive chemotherapy. N Engl J Med 19(332):143–149CrossRef
  Masternak MM, Bartke A (2012) Growth hormone, inflammation and aging. Pathol Aging Age Relat Dis 2:1–6
  Miller JFAP (1961) Immunological function of the thymus. Lancet 30:748–749CrossRef
  Mitchell WA, Lang PQ, Aspinall R (2010) Tracing thymic output in older individuals. Clin Exp Immunol 161:497–503PubMedCentral CrossRef PubMed
  Morrhaye G et al (2009) Impact of growth hormone (GH) deficiency and GH replacement upon thymus function in adults patients. PLoS ONE 4(5):e5668PubMedCentral CrossRef PubMed
  Palmer DB (2013) The effect of age on thymic function. Front Immunol 4:1–4CrossRef
  Panici JA, Harper JM, Miller RA, Bartke A, Spong A, Masternak MM (2010) Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice. FASEB J 24:5073-5-79CrossRef
  Pido-Lopez J, Imami N, Aspinall R (2001) Both age and gender affect output: more recent thymic migrants in female than males as they age. Clin Exp Immunol 125:409–413PubMedCentral CrossRef PubMed
  Polgreen L, Steiner M, Dietz CA, Manivel JC, Petryk A (2007) Thymic hyperplasia in a child treated with growth hormone. Growth Horm IGF Res 17(1):41–46CrossRef PubMed
  Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai N, Cohen P (2008) Functionally significant insulin-like growth factor 1 receptor mutations in centenarians. Proc Natl Acad Sci USA 105:3438–3442PubMedCentral CrossRef PubMed
  Taub DD, Murphy WJ, Longo DL (2010) Rejuvenation of the aging thymus: growth hormone and Ghrelin-mediated signaling pathways. Curr Opin Pharmacol 10:408–424PubMedCentral CrossRef PubMed
  Utsuyama M, Hirokawa K (1989) Hypertrophy of the thymus and restoration of immune functions in mice and rats by gonadectomy. Mech Ageing Dev 47:175–185CrossRef PubMed
  Utsuyama M, Kobayashi S, Hirokawa K (1997) Induction of thymic hyperplasia and suppression of splenic T cell by lesioning anterior hypothalamus. J Neuroimmunol 77:171–180CrossRef
  van Heemst D (2010) Insulin, IGF-1 and longevity. Aging Dis 1:147–157PubMedCentral PubMed
  Yamada A, Arakaki R, Tsunematsu T, Kudo Y, Hayashi Y, Ishimaru N (2015) Impaired expansion of regulatory T cells in a neonatal thymectomy-induced autoimmune mouse model. Am J Pathol (in press)
  
• 作者单位：Katsuiku Hirokawa (1)
  Masanori Utsuyama (1)
  Yuko Kikuchi (1)
  
  1. Institute for Health and Life Sciences, Tokyo Medical & Dental University Open Laboratory, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Geriatrics and Gerontology
  Developmental Biology
  
• 出版者：Springer Netherlands
• ISSN：1573-6768

文摘

High level of growth hormone (GH) is necessary for the activation of thymic function to promote T cell differentiation in the early stage of animal life. In the later stage of the life, administration of GH promotes the development of immune system and rejuvenates declined immune function of elderly people. By contraries, GH deficiency is favorable for the longer lifespan, as hypo-pituitary dwarf mice such as Ames and Snell dwarf mice exhibit longer lifespan than control. Furthermore over-expression of heterologous or homologous GH in transgenic mice shortens the lifespan. Ecuadorians carrying mutations of GH receptor gene are short in height, but exhibited low frequency of malignancy and no cases of diabetes. These data indicate that GH is necessary for the development of thymus dependent immune system but GH deficiency is favorable for long life span and decreases occurrence of cancer and DM. This situation is a kind of trade off situation between the immune system and GH. Thus the early decline of high level of GH occurring shortly after the birth is a cause of early decline of thymic functions, but favorable for longer lifespan. This situation could be a kind of trade off situation between thymus and GH. Keywords Thymus Growth hormone Immune system IgF-1 Lifespan Hypopituitary dwarf mice Transgenic mice