Rs1800625 in the receptor for advanced glycation end products gene predisposes to sepsis and multiple organ dysfunction syndrome in patients with major trauma

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• 作者：Ling Zeng (1)
  Juan Du (1)
  Wei Gu (1)
  An-qiang Zhang (1)
  Hai-yan Wang (1)
  Da-lin Wen (1)
  Lin Qiu (2)
  Xue-tao Yang (1)
  Jian-hui Sun (1)
  Mao Zhang (3)
  Jiang Hao (4)
  Jian-xin Jiang (1)
  
  1. State Key Laboratory of Trauma ; Burns and Combined Injury ; Institute of Surgery Research ; Daping Hospital ; Third Military Medical University ; 10 Changjiang Road ; Yuzhong District ; Daping ; Chongqing ; 400042 ; China
  2. Biochemistry and Molecular Biology Laboratory of Experiment Teaching Center ; Chongqing Medical University ; Fengyu Road ; Chongqing ; 401331 ; China
  3. Department of Emergency Medical Center ; the Second Affiliated Hospital ; Zhejiang University ; 88 Jiefang Road ; Zhejiang ; 310009 ; China
  4. Kunming General Hospital ; Chengdu Military of PLA ; 212 Grand View Road ; Kunming ; Yunnan ; 650032 ; China
  
• 刊名：Critical Care
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：19
• 期：1
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• 刊物主题：Intensive / Critical Care Medicine; Emergency Medicine;
• 出版者：BioMed Central
• ISSN：1364-8535

文摘

Introduction The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, it plays pivotal roles in the pathogenesis of sepsis in several ways. Our previous study showed that rs1800625 (鈭?29T/C) revealed a strong clinical relevance with sepsis morbidity rate and multiple organ dysfunction syndrome (MODS) in patients with major trauma. In this study, we enlarged the sample size, added two validation populations and examined the expression of RAGE on the surface of peripheral leukocytes to ex vivo lipopolysaccharide (LPS) stimulation in subjects with different genotypes. Methods Rs1800625 was genotyped using pyrosequencing in 837 Chinese Han patients with major trauma in Chongqing. We then validated the clinical relevance in 340 Zhejiang and 347 Yunnan patients. The expression of RAGE on the surface of peripheral blood mononuclear cells was measured by flow cytometric analysis. Results The results indicated that rs1800625 was significantly associated with sepsis morbidity rate and MODS in patients with major trauma in the Chongqing, Zhejiang and Yunnan districts. Patients with CC genotype had lower sepsis morbidity rate and MODS after major trauma. Furthermore, patients with CC genotype had significantly higher RAGE expression (P鈥?鈥?.009). Conclusions The rs1800625 polymorphism is a functional single nucleotide polymorphism and confers host susceptibility to sepsis and MODS in patients with major trauma.