Erythroleukemia Presenting as Non-immune Haemolytic Anemia: A Rare Presentation

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• 作者：Aastha Gupta (1)
  Swasti Sinha (1)
  Shyam Aggarwal (2)
  M. Bhargava (1)
  
  1. Department of Hematology ; Sir Ganga Ram Hospital ; First Floor ; SSRB Building ; Rajender Nagar ; New Delhi ; India
  2. Department of Oncology ; Sir Ganga Ram Hospital ; New Delhi ; India
  
• 关键词：Erythroleukemia ; Non ; immune haemolysis ; Acute Myeloid Leukemia
• 刊名：Indian Journal of Hematology and Blood Transfusion
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：30
• 期：1-supp
• 页码：219-222
• 全文大小：983 KB
• 参考文献：1. Arber, DA, Brunning, RD, Orazi, A Acute myeloid leukaemia, not otherwise specified. In: Swerdlow, SH, Campo, E, Harris, NL, Jaffe, ES, Pileri, SA, Stein, H, Thiele, J, Vardiman, JW eds. (2008) WHO classification of tumours of haematopoietic and lymphoid tissue. International Agency for research On Cancer (IARC), Lyon, pp. 130-139
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  3. Sachs, UJH, R枚der, L, Santoso, S (2006) Does a negative direct antiglobulin test exclude warm autoimmune haemolytic anaemia? A prospective study of 504 cases. Br J Haematol 132: pp. 655-656 CrossRef
  4. Kamesaki, T, Toyotsuji, T, Kajii, E (2013) Characterization of direct antiglobulin test-negative autoimmune hemolytic anemia: a study of 154 cases. Am J Hematol 88: pp. 93-96 CrossRef
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  7. Al-Zahrani, H, AbuJaafar, S, Bakshi, N (2011) Non immune haemolysis: An unusual presenting feature of acute erythroleukemia. J Appl Haematol 44: pp. 207-209
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• 刊物主题：Hematology; Oncology; Blood Transfusion Medicine; Human Genetics;
• 出版者：Springer India
• ISSN：0974-0449

文摘

Non-immune haemolysis is a rare manifestation of acute leukaemia and more so in acute myeloid leukemia. Here, we report a case of non-immune and non-fragmentation haemolysis as the initial presenting manifestation in a 55-year-old female with acute myeloid leukaemia (AML-M6). All other potential aetiologies of haemolysis were excluded, including drugs, paroxysmal nocturnal haemoglobinuria, immune and other known congenital and acquired causes of haemolytic anaemia. This case shows that malignant haematopoietic disorders should be considered in patients with newly diagnosed haemolysis.