Competing endogenous RNA interplay in cancer: mechanism, methodology, and perspectives
详细信息 查看全文
- 作者：Dong-Liang Cheng (1)
Yuan-Yuan Xiang (2)
Li-juan Ji (3)
Xiao-Jie Lu (4)
1. Department of Cardiothoracic Surgery ; Shiyan Taihe Hospital ; Hubei University of Medicine ; Shiyan City ; Hubei Province ; China
2. Cervical disease clinic ; Jiangsu Huai鈥檃n Maternity and Children Hospital ; Huai鈥檃n ; China
3. Department of Rehabilitation ; The Second People鈥檚 Hospital of Huai鈥檃n ; Huai鈥檃n ; China
4. Department of Gastroenterology ; Shanghai East Hospital ; Tongji University ; School of Medicine ; Shanghai ; China - 关键词：ceRNA ; Cancer ; miRNA ; miRNA response elements
- 刊名：Tumor Biology
- 出版年：2015
- 出版时间：February 2015
- 年：2015
- 卷：36
- 期：2
- 页码：479-488
- 全文大小：736 KB
- 参考文献：Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489: pp. 57-74 nal" href="http://dx.doi.org/10.1038/nature11247" target="_blank" title="It opens in new window">CrossRef
1. Bartel, DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136: pp. 215-33 nal" href="http://dx.doi.org/10.1016/j.cell.2009.01.002" target="_blank" title="It opens in new window">CrossRef
2. Poliseno, L, Salmena, L, Zhang, J, Carver, B, Haveman, WJ, Pandolfi, PP (2010) A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 465: pp. 1033-1038 nal" href="http://dx.doi.org/10.1038/nature09144" target="_blank" title="It opens in new window">CrossRef
3. Tay, Y, Kats, L, Salmena, L, Weiss, D, Tan, SM, Ala, U (2011) Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell 147: pp. 344-357 nal" href="http://dx.doi.org/10.1016/j.cell.2011.09.029" target="_blank" title="It opens in new window">CrossRef
4. Salmena, L, Poliseno, L, Tay, Y, Kats, L, Pandolfi, PP (2011) A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?. Cell 146: pp. 353-358 nal" href="http://dx.doi.org/10.1016/j.cell.2011.07.014" target="_blank" title="It opens in new window">CrossRef
5. Li, N, Flynt, AS, Kim, HR, Solnica-Krezel, L, Patton, JG (2008) Dispatched Homolog 2 is targeted by miR-214 through a combination of three weak microRNA recognition sites. Nucleic Acids Res 36: pp. 4277-85 nal" href="http://dx.doi.org/10.1093/nar/gkn388" target="_blank" title="It opens in new window">CrossRef
6. Brennecke, J, Stark, A, Russell, RB, Cohen, SM (2005) Principles of microRNA-target recognition. PLoS Biol 3: pp. e85 nal" href="http://dx.doi.org/10.1371/journal.pbio.0030085" target="_blank" title="It opens in new window">CrossRef
7. Wang, B, Love, TM, Call, ME, Doench, JG, Novina, CD (2006) Recapitulation of short RNA-directed translational gene silencing in vitro. Mol Cell 22: pp. 553-560 nal" href="http://dx.doi.org/10.1016/j.molcel.2006.03.034" target="_blank" title="It opens in new window">CrossRef
8. Chi, SW, Zang, JB, Mele, A, Darnell, RB (2009) Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature 460: pp. 479-86
9. Qiu, MT, Hu, JW, Yin, R, Xu, L (2013) Long noncoding RNA: an emerging paradigm of聽cancer聽research. Tumour Biol 34: pp. 613-20 nal" href="http://dx.doi.org/10.1007/s13277-013-0658-6" target="_blank" title="It opens in new window">CrossRef
10. Li, CH, Chen, Y (2013) Targeting long non-coding RNAs in cancers: progress and prospects. Int J Biochem Cell Biol 45: pp. 1895-910 nal" href="http://dx.doi.org/10.1016/j.biocel.2013.05.030" target="_blank" title="It opens in new window">CrossRef
11. Deng, K, Guo, X, Wang, H, Xia, J (2014) The聽lncRNA-MYC regulatory network in聽cancer. Tumour Biol 35: pp. 9497-503 nal" href="http://dx.doi.org/10.1007/s13277-014-2511-y" target="_blank" title="It opens in new window">CrossRef
12. Penny, GD, Kay, GF, Sheardown, SA, Rastan, S, Brockdorff, N (1996) Requirement for Xist in X chromosome inactivation. Nature 379: pp. 131-137 nal" href="http://dx.doi.org/10.1038/379131a0" target="_blank" title="It opens in new window">CrossRef
13. Wang, J, Liu, X, Wu, H, Ni, P, Gu, Z, Qiao, Y (2010) CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res 38: pp. 5366-5383 nal" href="http://dx.doi.org/10.1093/nar/gkq285" target="_blank" title="It opens in new window">CrossRef
14. Liu, XH, Sun, M, Nie, FQ, Ge, YB, Zhang, EB, Yin, DD (2014) Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer 13: pp. 92 nal" href="http://dx.doi.org/10.1186/1476-4598-13-92" target="_blank" title="It opens in new window">CrossRef
15. Zhou, X, Gao, Q, Wang, J, Zhang, X, Liu, K, Duan, Z (2014) Linc-RNA-RoR acts as a "sponge" against mediation of the differentiation of endometrial cancer stem cells by microRNA-145. Gynecol Oncol 133: pp. 333-9 nal" href="http://dx.doi.org/10.1016/j.ygyno.2014.02.033" target="_blank" title="It opens in new window">CrossRef
16. Xiao-Jie, L, Ai-Mei, G, Li-Juan, J, Jiang, X (2015) Pseudogene in cancer: real functions and promising signature. J Med Genet 52: pp. 17-24 nal" href="http://dx.doi.org/10.1136/jmedgenet-2014-102785" target="_blank" title="It opens in new window">CrossRef
17. Yu, G, Yao, W, Gumireddy, K, Li, A, Wang, J, Xiao, W (2014) Pseudogene PTENP1 Functions as a Competing Endogenous RNA to Suppress Clear-Cell Renal Cell Carcinoma Progression. Mol Cancer Ther 13: pp. 3086-97 nal" href="http://dx.doi.org/10.1158/1535-7163.MCT-14-0245" target="_blank" title="It opens in new window">CrossRef
18. Capel, B, Swain, A, Nicolis, S, Hacker, A, Walter, M, Koopman, P (1993) Circular transcripts of the testis-determining gene Sry in adult mouse testis. Cell 73: pp. 1019-1030 nal" href="http://dx.doi.org/10.1016/0092-8674(93)90279-Y" target="_blank" title="It opens in new window">CrossRef
19. Hansen, TB, Jensen, TI, Clausen, BH, Bramsen, JB, Finsen, B, Damgaard, CK (2013) Natural RNA circles function as efficient microRNA sponges. Nature 495: pp. 384-8 nal" href="http://dx.doi.org/10.1038/nature11993" target="_blank" title="It opens in new window">CrossRef
20. Fang, L, Du, WW, Yang, X, Chen, K, Ghanekar, A, Levy, G (2013) Versican 3使-untranslated region (3使-UTR) functions as a ceRNA in inducing the development of hepatocellular carcinoma by regulating miRNA activity. FASEB J 27: pp. 907-919 nal" href="http://dx.doi.org/10.1096/fj.12-220905" target="_blank" title="It opens in new window">CrossRef
21. Wang, L, Guo, ZY, Zhang, R, Xin, B, Chen, R, Zhao, J (2013) Pseudogene OCT4-pg4 functions as a natural micro RNA sponge to regulate OCT4 expression by competing for miR-145 in hepatocellular carcinoma. Carcinogenesis 34: pp. 1773-1781 nal" href="http://dx.doi.org/10.1093/carcin/bgt139" target="_blank" title="It opens in new window">CrossRef
22. Lee, DY, Jeyapalan, Z, Fang, L, Yang, J, Zhang, Y, Yee, AY (2010) Expression of versican 3使-untranslated region modulates endogenous microRNA functions. PLoS ONE 5: pp. e13599 nal" href="http://dx.doi.org/10.1371/journal.pone.0013599" target="_blank" title="It opens in new window">CrossRef
23. Jeyapalan, Z, Deng, Z, Shatseva, T, Fang, L, He, C, Yang, BB (2011) Expression of CD44 30-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis. Nucleic Acids Res 39: pp. 3026-41 nal" href="http://dx.doi.org/10.1093/nar/gkq1003" target="_blank" title="It opens in new window">CrossRef
24. Rutnam, ZJ, Yang, BB (2012) The non-coding 3' UTR of CD44 induces metastasis by regulating extracellular matrix functions. J Cell Sci 125: pp. 2075-85 nal" href="http://dx.doi.org/10.1242/jcs.100818" target="_blank" title="It opens in new window">CrossRef
25. Yang, J, Li, T, Gao, C, Lv, X, Liu, K, Song, H (2014) FOXO1 3'UTR functions as a ceRNA in repressing the metastases of breast cancer cells via regulating miRNA activity. FEBS Lett 588: pp. 3218-24 nal" href="http://dx.doi.org/10.1016/j.febslet.2014.07.003" target="_blank" title="It opens in new window">CrossRef
26. Kumar, MS, Armenteros-Monterroso, E, East, P, Chakravorty, P, Matthews, N, Winslow, MM (2014) HMGA2 functions as a competing endogenous RNA to promote lung cancer progression. Nature 505: pp. 212-7 nal" href="http://dx.doi.org/10.1038/nature12785" target="_blank" title="It opens in new window">CrossRef
27. Liu, K, Guo, L, Guo, Y, Zhou, B, Li, T, Yang, H (2015) AEG-1 3'-untranslated region functions as a聽ceRNA聽in inducing epithelial-mesenchymal transition of human non-small cell lung聽cancer聽by regulating miR-30a activity. Eur J Cell Biol 94: pp. 22-31 nal" href="http://dx.doi.org/10.1016/j.ejcb.2014.10.006" target="_blank" title="It opens in new window">CrossRef
28. Karreth, FA, Tay, Y, Perna, D, Ala, U, Tan, SM, Rust, AG (2011) In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell 147: pp. 382-395 nal" href="http://dx.doi.org/10.1016/j.cell.2011.09.032" target="_blank" title="It opens in new window">CrossRef
29. Sumazin, P, Yang, X, Chiu, HS, Chung, WJ, Iyer, A, Llobet-Navas, D (2011) An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma. Cell 147: pp. 370-381 nal" href="http://dx.doi.org/10.1016/j.cell.2011.09.041" target="_blank" title="It opens in new window">CrossRef
30. Ebert, MS, Sharp, PA (2010) Emerging roles for natural microRNA sponges. Curr Biol 20: pp. R858-R861 nal" href="http://dx.doi.org/10.1016/j.cub.2010.08.052" target="_blank" title="It opens in new window">CrossRef
31. Mukherji, S, Ebert, MS, Zheng, GXY, Tsang, JS, Sharp, PA, Oudenaarden, A (2011) MicroRNAs can generate thresholds in target gene expression. Nat Genet 43: pp. 854-859 nal" href="http://dx.doi.org/10.1038/ng.905" target="_blank" title="It opens in new window">CrossRef
32. Figliuzzi, M, Marinari, E, Martino, A (2013) MicroRNAs as a selective channel of communication between competing RNAs: a steady-state theory. Biophys J 104: pp. 1203-1213 nal" href="http://dx.doi.org/10.1016/j.bpj.2013.01.012" target="_blank" title="It opens in new window">CrossRef
33. Pal, S, Gupta, R, Davuluri, RV (2012) Alternative transcription and alternative splicing in cancer. Pharmacol Ther 136: pp. 283-294 nal" href="http://dx.doi.org/10.1016/j.pharmthera.2012.08.005" target="_blank" title="It opens in new window">CrossRef
34. Zhou, X, Li, X, Cheng, Y, Wu, W, Xie, Z, Xi, Q (2014) BCLAF1 and its聽splicing聽regulator SRSF10 regulate the tumorigenic potential of colon聽cancer聽cells. Nat Commun.
35. Xu, Y, Gao, XD, Lee, JH, Huang, H, Tan, H, Ahn, J (2014) Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulatingalternative splicing. Genes Dev 28: pp. 1191-203 nal" href="http://dx.doi.org/10.1101/gad.241968.114" target="_blank" title="It opens in new window">CrossRef
36. Venables, JP, Klinck, R, Koh, C, Gervais-Bird, J, Bramard, A, Inkel, L (2009) Cancer-associated regulation of alternative splicing. Nature Struct Mol Biol 16: pp. 670-676 nal" href="http://dx.doi.org/10.1038/nsmb.1608" target="_blank" title="It opens in new window">CrossRef
37. Mayr, C, Bartel, DP (2009) Widespread shortening of 3使UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell 138: pp. 673-684 nal" href="http://dx.doi.org/10.1016/j.cell.2009.06.016" target="_blank" title="It opens in new window">CrossRef
38. Lembo, A, Cunto, F, Provero, P (2012) Shortening of 3使UTRs correlates with poor prognosis in breast and lung cancer. PLoS ONE 7: pp. e31129 nal" href="http://dx.doi.org/10.1371/journal.pone.0031129" target="_blank" title="It opens in new window">CrossRef
39. Lau, CC, Sun, T, Ching, AK, He, M, Li, JW, Wong, AM (2014) Viral-human chimeric transcript predisposes risk to liver cancer development and progression. Cancer Cell 25: pp. 335-49 nal" href="http://dx.doi.org/10.1016/j.ccr.2014.01.030" target="_blank" title="It opens in new window">CrossRef
40. Park, K, Dalton, JT, Narayanan, R, Barbieri, CE, Hancock, ML, Bostwick, DG (2014) TMPRSS2:ERG聽gene fusion聽predicts subsequent detection of prostate聽cancer聽in patients with high-grade prostatic intraepithelial neoplasia. J Clin Oncol 32: pp. 206-11 nal" href="http://dx.doi.org/10.1200/JCO.2013.49.8386" target="_blank" title="It opens in new window">CrossRef
41. Li, F, Feng, Y, Fang, R, Fang, Z, Xia, J, Han, X (2012) Viral-human chimeric transcript predisposes risk to liver cancer development and progression. Cell Res 22: pp. 928-31 nal" href="http://dx.doi.org/10.1038/cr.2012.27" target="_blank" title="It opens in new window">CrossRef
42. Almeida, MI, Reis, RM, Calin, GA (2012) Decoy activity through microRNAs: the therapeutic implications. Expert Opin Biol Ther 12: pp. 1153-1159 nal" href="http://dx.doi.org/10.1517/14712598.2012.693470" target="_blank" title="It opens in new window">CrossRef
43. Sabarinathan, R, Wenzel, A, Novotny, P, Tang, X, Kalari, KR, Gorodkin, J (2014) Transcriptome-wide analysis of UTRs in non-small cell lung cancer reveals cancer-related genes with SNV-induced changes on聽RNA secondary structure聽and聽miRNA聽target sites. PLoS One 9: pp. e82699 nal" href="http://dx.doi.org/10.1371/journal.pone.0082699" target="_blank" title="It opens in new window">CrossRef
44. Maas, S (2012) Posttranscriptional recoding by RNA editing. Adv Protein Chem Struct Biol 86: pp. 193-224 nal" href="http://dx.doi.org/10.1016/B978-0-12-386497-0.00006-2" target="_blank" title="It opens in new window">CrossRef
45. Kawahara, Y, Megraw, M, Kreider, E, Iizasa, H, Valente, L, Hatzigeorgiou, AG (2008) Frequency and fate of microRNA editing in human brain. Nucleic Acids Res 36: pp. 5270-5280 nal" href="http://dx.doi.org/10.1093/nar/gkn479" target="_blank" title="It opens in new window">CrossRef
46. Levanon, EY, Eisenberg, E, Yelin, R, Nemzer, S, Hallegger, M, Shemesh, R (2004) Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nature Biotechnol 22: pp. 1001-1005 nal" href="http://dx.doi.org/10.1038/nbt996" target="_blank" title="It opens in new window">CrossRef
47. Young, LE, Moore, AE, Sokol, L, Meisner-Kober, N, Dixon, DA (2012) The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2. Mol Cancer Res 10: pp. 167-180 nal" href="http://dx.doi.org/10.1158/1541-7786.MCR-11-0337" target="_blank" title="It opens in new window">CrossRef
48. Epis, MR, Barker, A, Giles, KM, Beveridge, DJ, Leedman, PJ (2011) The RNA-binding protein HuR opposes the repression of ERBB-2 gene expression by microRNA miR-331鈥?p in prostate cancer cells. J Biol Chem 286: pp. 41442-41454 nal" href="http://dx.doi.org/10.1074/jbc.M111.301481" target="_blank" title="It opens in new window">CrossRef
49. Kim, HH, Kuwano, Y, Srikantan, S, Lee, EK, Martindale, JL, Gorospe, M (2009) HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev 23: pp. 1743-1748 nal" href="http://dx.doi.org/10.1101/gad.1812509" target="_blank" title="It opens in new window">CrossRef
50. Ala, U, Karreth, FA, Bosia, C, Pagnani, A, Taulli, R, L茅opold, V (2013) Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments. Proc Natl Acad Sci U S A 110: pp. 7154-7159 nal" href="http://dx.doi.org/10.1073/pnas.1222509110" target="_blank" title="It opens in new window">CrossRef
51. Li, JH, Liu, S, Zhou, H, Qu, LH, Yang, JH (2014) starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein鈥揜NA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res 42: pp. D92-7 nal" href="http://dx.doi.org/10.1093/nar/gkt1248" target="_blank" title="It opens in new window">CrossRef
52. Sarver, AL, Subramanian, S (2012) Competing endogenous RNA database. Bioinformation 8: pp. 731-733 nal" href="http://dx.doi.org/10.6026/97320630008731" target="_blank" title="It opens in new window">CrossRef
53. Miranda, KC, Huynh, T, Tay, Y, Ang, YS, Tam, WL, Thomson, AM (2006) A pattern-based method for the identification of microRNA binding sites and their corresponding heteroduplexes. Cell 126: pp. 1203-1217 nal" href="http://dx.doi.org/10.1016/j.cell.2006.07.031" target="_blank" title="It opens in new window">CrossRef
54. Hafner, M, Landthaler, M, Burger, L, Khorshid, M, Hausser, J, Berninger, P (2010) Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell 141: pp. 129-41 nal" href="http://dx.doi.org/10.1016/j.cell.2010.03.009" target="_blank" title="It opens in new window">CrossRef
55. Thomson, DW, Bracken, CP, Goodall, GJ (2011) Experimental strategies for microRNA target identification. Nucleic Acids Res 39: pp. 6845-6853 nal" href="http://dx.doi.org/10.1093/nar/gkr330" target="_blank" title="It opens in new window">CrossRef
56. Yoon, JH, Srikantan, S, Gorospe, M (2012) MS2-TRAP (MS2-tagged RNA affinity purification): tagging RNA to identify associated miRNAs. Methods 58: pp. 81-87 nal" href="http://dx.doi.org/10.1016/j.ymeth.2012.07.004" target="_blank" title="It opens in new window">CrossRef
57. Schug, J, McKenna, LB, Walton, G, Hand, N, Mukherjee, S, Essuman, K (2013) Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver. BMC Genomics.
58. Memczak, S, Jens, M, Elefsinioti, A, Torti, F, Krueger, J, Rybak, A (2013) Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 495: pp. 333-8 nal" href="http://dx.doi.org/10.1038/nature11928" target="_blank" title="It opens in new window">CrossRef
59. Jeck, WR, Sorrentino, JA, Wang, K, Slevin, MK, Burd, CE, Liu, J (2013) Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA 19: pp. 141-57 nal" href="http://dx.doi.org/10.1261/rna.035667.112" target="_blank" title="It opens in new window">CrossRef
60. Salzman, J, Gawad, C, Wang, PL, Lacayo, N, Brown, PO (2012) Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS ONE 7: pp. e30733 nal" href="http://dx.doi.org/10.1371/journal.pone.0030733" target="_blank" title="It opens in new window">CrossRef
61. Taulli, R, Loretelli, C, Pandolfi, PP (2013) From pseudo-ceRNAs to circ-ceRNAs: a tale of cross-talk and competition. Nature Struct Mol Biol 20: pp. 541-543 nal" href="http://dx.doi.org/10.1038/nsmb.2580" target="_blank" title="It opens in new window">CrossRef
62. Wilusz, JE, Sharp, PA (2013) Molecular biology. A circuitous route to noncoding RNA. Science 340: pp. 440-441 nal" href="http://dx.doi.org/10.1126/science.1238522" target="_blank" title="It opens in new window">CrossRef
63. Tollervey, D (2006) Molecular biology: RNA lost in translation. Nature 440: pp. 425-426 nal" href="http://dx.doi.org/10.1038/440425a" target="_blank" title="It opens in new window">CrossRef
64. Dey, N, Das, F, Ghosh-Choudhury, N, Mandal, CC, Parekh, DJ, Block, K (2012) microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion. PLoS One 7: pp. e37366 nal" href="http://dx.doi.org/10.1371/journal.pone.0037366" target="_blank" title="It opens in new window">CrossRef
65. Xu, G, Zhang, Y, Wei, J, Jia, W, Ge, Z, Zhang, Z (2013) MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen activated protein kinase-kinase 3. BMC Cancer.
66. Mandal, CC, Ghosh-Choudhury, T, Dey, N, Choudhury, GG, Ghosh-Choudhury, N (2012) miR-21 is targeted by omega-3 polyunsaturated fatty acid to regulate breast tumor CSF-1 expression. Carcinogenesis 33: pp. 1897-1908 nal" href="http://dx.doi.org/10.1093/carcin/bgs198" target="_blank" title="It opens in new window">CrossRef
67. Lin, J, Teo, S, Lam, DH, Jeyaseelan, K, Wang, S (2012) MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme. Cell Death Dis.
68. Li, Q, Li, X, Guo, Z, Xu, F, Xia, J, Liu, Z (2012) MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor in human lung cancer. PLoS One 7: pp. e48278 nal" href="http://dx.doi.org/10.1371/journal.pone.0048278" target="_blank" title="It opens in new window">CrossRef
69. Lin, CW, Chang, YL, Chang, YC, Lin, JC, Chen, CC, Pan, SH (2013) MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS. Nat Commun.
70. Liu, Y, Cui, H, Wang, W, Li, L, Wang, Z, Yang, S (2013) Construction of circular miRNA sponges targeting miR-21 or miR-221 and demonstration of their excellent anticancer effects on malignant melanoma cells. Int J Biochem Cell Biol 45: pp. 2643-2650 nal" href="http://dx.doi.org/10.1016/j.biocel.2013.09.003" target="_blank" title="It opens in new window">CrossRef
71. Dylla, L, Jedlicka, P (2013) Growth-promoting role of the miR-106a鈥?63 cluster in Ewing sarcoma. PLoS One 8: pp. e63032 nal" href="http://dx.doi.org/10.1371/journal.pone.0063032" target="_blank" title="It opens in new window">CrossRef - 刊物主题：Cancer Research;
- 出版者：Springer Netherlands
- ISSN：1423-0380
文摘
Competing endogenous RNAs (ceRNAs) refer to RNA transcripts, such as mRNAs, non-coding RNAs, pseudogene transcripts, and circular RNAs, that can regulate each other by competing for the same pool of miRNAs. ceRNAs involve in the pathogenesis of several common cancers such as prostate cancer, liver cancer, breast cancer, lung cancer, gastric cancer, endometrial cancer, and so on. ceRNA activity is determined by factors such as miRNA/ceRNA abundance, ceRNAs binding affinity to miRNAs, RNA editing, and RNA-binding proteins. The alteration of any of these factors may lead to ceRNA network imbalance and thus contribute to cancer initiation and progression. There are generally three steps in ceRNA research conductions: ceRNA prediction, ceRNA validation, and ceRNA functional investigation. Deciphering ceRNA interplay in cancer provides new insight into cancer pathogenesis and opportunities for therapy exploration. In this review, we try to give readers a concise and reliable illustration on the mechanism, functions, research approaches, and perspective of ceRNA in cancer.