Acceptability of prenatal testing and termination of pregnancy in Pakistan

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• 作者：H. Jafri (1)
  J. Hewison (2)
  E. Sheridan (3)
  S. Ahmed (2)
  
  1. Genetech Laboratory ; 146/1 Shadman Jail Road ; Lahore ; Pakistan
  2. Leeds Institute of Health Sciences ; University of Leeds ; 101 Clarendon Road ; Leeds ; LS2 9LJ ; UK
  3. Yorkshire Regional Genetics Service ; Leeds NHS Teaching Hospitals Trust ; Leeds ; UK
  
• 关键词：Prenatal testing ; Termination ; Mothers ; Fathers ; Pakistan
• 刊名：Journal of Community Genetics
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：6
• 期：1
• 页码：29-37
• 全文大小：846 KB
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• 刊物主题：Human Genetics; Public Health; Epidemiology; Gene Therapy; Gene Function;
• 出版者：Springer Berlin Heidelberg
• ISSN：1868-6001

文摘

This study aimed to assess acceptability of prenatal testing (PNT) and termination of pregnancy (TOP) for a range of conditions in Pakistani parents with and without a child with a genetic condition. A structured questionnaire assessing acceptability of PNT and TOP for 30 conditions was completed by 400 Pakistani participants: 200 parents with a child with a genetic condition (100 fathers and 100 mothers) and 200 parents without an affected child (100 fathers and 100 mothers). There was a high level of interest in PNT, where over 80 % of parents in all four study groups would want PNT for the majority of the conditions. There was comparatively less interest in TOP for the same conditions (ranging from 5 to 70 % of parents, with mothers of an affected child being most interested). Parents were most likely to be interested in TOP for conditions at the serious end of the continuum. More than half of the participants in each group would consider TOP for anencephaly and quadriplegia. The interest in PNT and TOP for a range of conditions suggests that rapidly developing PNT technologies are likely to be acceptable in Pakistan, a low-middle income level and Muslim country. The comparatively lower level of interest in TOP for the same conditions highlights ethical dilemmas that such technologies are likely to raise.