Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh
详细信息 查看全文
- 作者：Khairul Islam (1)
Abedul Haque (1)
Rezaul Karim (1) (2)
Abul Fajol (1)
Ekhtear Hossain (1)
Kazi Abdus Salam (1)
Nurshad Ali (1)
Zahangir Alam Saud (1)
Matiar Rahman (1)
Mashiur Rahman (1)
Rezaul Karim (3)
Papia Sultana (4)
Mostaque Hossain (5)
Anwarul Azim Akhand (6)
Abul Mandal (7)
Hideki Miyataka (8)
Seiichiro Himeno (8)
Khaled Hossain (1) - 刊名：Environmental Health
- 出版年：2011
- 出版时间：December 2011
- 年：2011
- 卷：10
- 期：1
- 全文大小：352KB
- 参考文献：1. Chakraborti D, Sengupta MK, Rahman MM, Ahmed S, Chowdhury UK, Hossain MA, Mukherjee SC, Pati S, Saha KC, Dutta RN, Quamruzzaman Q: Groundwater arsenic contamination and its health effects in the Ganga-Meghna-Brahmaputra plain. / J Environ Monit 2004, 6:74鈥?3. CrossRef
2. Bissen M, Frimmel FH: Arsenic - a review. Part-I: Occurrence, toxicity and speciation, and mobility. / Acta Hydrochim Hydrobiol 2003, 31:9鈥?8. CrossRef
3. Bissen M, Frimmel FH: Arsenic - a review. Part-II: Oxidation of arsenic and its removal in water treatment. 2003, 31:97鈥?07.
4. IARC (International Agency for Research on Cancer): Monographs on evaluation of carcinogenic risk to humans. In: Some Drinking Water Disinfectants and Contaminants, including Arsenic. 2004, 84:269鈥?77.
5. Bertolero F, Pozzi G, Sabbioni E, Saffiotti U: Cellular uptake and metabolic reduction of pentavalent to trivalent arsenic as determinants of cytotoxicity and morphological transformation. / Carcinogenesis 1987, 8:80鈥?8. CrossRef
6. Vahter M, Concha G: Role of metabolism in arsenic toxicity. / Pharmacol Toxico 2001, 89:1鈥?. CrossRef
7. Rossman TG, Uddin AN, Burns FJ: Evidence that arsenite acts as a cocarcinogen in skin cancer. / Toxicol Appl Pharmacol 2004, 198:394鈥?04. CrossRef
8. Thomas DJ, Waters SB, Styblo M: Elucidating the pathway for arsenic methylation. / Toxicol Appl Pharmacol 2004, 198:319鈥?26. CrossRef
9. Sambu S, Wilson R: Arsenic in food and water-a brief history. / Toxicol Ind Health 2008, 24:217鈥?26. CrossRef
10. WHO: Arsenic in drinking water resulting in arsenic toxicity in India and Bangladesh. [http://www.searo.who.int/LinkFiles/Arsenic_Mitigation_arsDinRecomReports(1997).pdf] 2010.
11. Chowdhury UK, Biswas BK, Chowdhury TR, Samanta G, Mandal BK, Basu GC, Chanda CR, Lodh D, Saha KC, Mukherjee SK, Roy S, Kabir S, Quamruzzamen Q, Chakraborti D: Groundwater arsenic contamination in Bangladesh and West Bengal, India. / Environ Health Perspect 2000, 108:393鈥?97. CrossRef
12. BGS (British Geological Survey) and DPHE (Department of Public Health Engineering, Bangladesh): Arsenic Contamination of Groundwater in Bangladesh. Keyworth, UK:British Geological Survey; 2010., 2: [http://www.sos-arsenic.net/english/toxic_effect/index.html], Final Report. (Kinniburg DG, Smedley PL, eds) BGS Technical Report WC/00/19.
13. Khan MM, Sakauchi F, Sonoda T, Washio M, Mori M: Magnitude of arsenic toxicity in tube-well drinking water in Bangladesh and its adverse effects on human health including cancer: evidence from a review of the literature. / Asian Pac J Cancer Prev 2003, 4:7鈥?4.
14. Wang CH, Jeng JS, Yip PK, Chen CL, Hsu LI, Hsueh YM, Chiou HY, Wu MM, Chen CJ: Biological gradient between long-term arsenic exposure and carotid atherosclerosis. / Circulation 2002, 105:1804鈥?809. CrossRef
15. Vahidnia A, Romijn F, van der Voet GB, de Wolff FA: Arsenic-induced neurotoxicity in relation to toxicokinetics: Effects on sciatic nerve proteins. / Chem Biol Interact 2008, 176:188鈥?95. CrossRef
16. Chen CJ, Wang SL, Chiou JM, Tseng CH, Chiou HY, Hsueh YM, Chen SY, Wu MM, Lai MS: Arsenic and diabetes and hypertension in human populations: a review. / Toxicol Appl Pharmacol 2007, 222:298鈥?04. CrossRef
17. Mumford JL, Wu K, Xia Y, Kwok R, Yang Z, Foster J, Sanders WE Jr: Chronic Arsenic Exposure and Cardiac Repolarization Abnormalities with QT Interval Prolongation in a Population-based Study. / Environ Health Perspect 2007, 115:690鈥?94. CrossRef
18. Tapio S, Grosche B: Arsenic in the aetiology of cancer. / Mutat Res 2006, 612:215鈥?46. CrossRef
19. Meliker JR, Wahl RL, Cameron LL, Nriagu JO: Arsenic in drinking water and cerebrovascular disease, diabetes mellitus, and kidney disease in Michigan: a standardized mortality ratio analysis. / Environ Health 2007, 2:4鈥?. CrossRef
20. Mazumder DNG, Haque R, Gosh N, De BK, Santra A, Chakraborty D, Smith AH: Arsenic levels in drinking water and the prevalence of skin lesions in West Bengal, India. / Int J Epidemio 1998, 27:871鈥?77. CrossRef
21. Li X, Pi J, Li B, Xu Y, Jin Y, Sun G: Urinary arsenic speciation and its correlation with 8鈥?HDG in Chinese residents exposed to arsenic through coal burning. / Bull Environ Contam Toxicol 2008, 81:406鈥?11. CrossRef
22. Cui X, Kobayashi Y, Hayakawa T, Hirano S: Arsenic speciation in bile and urine following oral and intravenous exposure to inorganic and organic arsenics in rats. / Toxicol Sci 2004, 82:478鈥?87. CrossRef
23. Colognato R, Coppede F, Ponti J, Sabbioni E, Migliore L: Genotoxicity induced by arsenic compounds in peripheral human lymphocytes analysed by cytokinesis-block micronucleus assay. / Mutagenesis 2007, 22:255鈥?61. CrossRef
24. Hossain K, Akhand AA, Kato M, Du J, Takeda K, Wu J, Takeuchi K, Liu W, Suzuki H, Nakashima I: Arsenite induces apoptosis of Murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase. / J Immunol 2000, 165:4290鈥?297.
25. Akhand AA, Du J, Liu W, Hossain K, Miyata T, Nagase F, Kato M, Suzuki H, Nakashima I: Redox-Linked Cell Surface-Oriented Signaling for T-Cell Death. / Antioxid Redox Signal 2002, 4:445鈥?54. CrossRef
26. Rossman TG: Mechanism of arsenic carcinogenesis: An integrated approach. / Mutat Res 2003, 533:37鈥?6.
27. Liu DN, Lu XZ, Li BL, Zhou DX, Li FX, Zheng DH, Wang KH: Clinical analysis of 535 cases of chronic arsenic poisoning from coal burning. / Chin J Med 1992, 31:560鈥?62.
28. Liu J, Zheng B, Aposhian HV, Zhou Y, Cheng ML, Zhang AH, Waalkes MP: Chronic arsenic poisoning from burning high-arsenic-containing coal in Guizhou, China. / Environ Health Perspect 2002, 110:119鈥?22. CrossRef
29. Zhou Y-S, Du H, Cheng M-L, Liu J, Zhang X-J, Xu L: The investigation of death from diseases caused by coal-burning type of arsenic poisoning. / Chin J Endemiol 2002, 21:484鈥?86.
30. Liaw J, Marshall G, Yuan Y, Ferreccio C, Steinmaus C, Smith AH: Increased childhood liver cancer mortality and arsenic in drinking water in northern Chile. / Cancer Epidemiol Biomarkers Prev 2008, 17:1982鈥?987. CrossRef
31. Toxic Effects of Arsenic [http://www.sos-arsenic.net/english/toxic_effect/index.html] 2010.
32. Rothschild MA, Oratz M, Schreiber SS: Albumin synthesis. 1. / N Engl J Med 1972, 286:748鈥?57. CrossRef
33. Schmidt E, Schmidt FW: Enzyme diagnosis of liver diseases. / Clin Biochem 1993, 26:241鈥?51. CrossRef
34. Scheig R: Evaluation of tests used to screen patients with liver disorders. / Prim Care 1996, 23:551鈥?60.
35. Ali N, Hoque MA, Haque A, Salam KA, Karim MR, Rahman A, Islam K, Saud ZA, Khalek MA, Akhand AA, Hossain M, Mandal A, Karim MR, Miyataka H, Himeno S, Hossain K: Association between arsenic exposure and plasma cholinesterase activity: a population based study in Bangladesh. / Environ Health 2010, 9:36. CrossRef
36. Karim MR, Salam KA, Hossain E, Islam K, Ali N, Haque A, Saud ZA, Yeasmin T, Hossain M, Miyataka H, Himeno S, Hossain K: Interaction between chronic arsenic exposure via drinking water and plasma lactate dehydrogenase activity. / Sci Total Environ 2010, 409:278鈥?83. CrossRef
37. Mazumder DNG: Effect of chronic intake of arsenic-contaminated water on liver. / Toxicol Appl Pharmacol 2005, 206:169鈥?75. CrossRef
38. Nabi AH, Rahman MM, Islam LN: Evaluation of Biochemical Changes in Chronic Arsenic Poisoning among Bangladeshi Patients. / Int J Environ Res Public Health 2005, 2:385鈥?93. CrossRef
39. Dalal B, Nayak K, Gangopadhyay PK, Mukherjee AK: Identification of indicators of arsenic induced hepatic damage in human. / The Internet Journal of Toxicology 2009.,7(1):
40. Van Green A, Zheng Y, Goodbred JRS, Horneman A, Aziz Z, Cheng Z, Stute M, Mailloux B, Weinman B, Hoque MA, Seddique AA, Hossain MS, Chowdhury SH, Ahmed KM: Flushing history as a hydrogeological control on the regional distribution of arsenic in shallow groundwater of the Bengal Basin. / Environmental Science and Technology 2008, 42:2283鈥?288. CrossRef
41. Ahsan H, Chen Y, Parvez F, Zablotska L, Argos M, Hussain I, Momotaj H, Levy D, Cheng Z, Slavkovich V, van Geen A, Howe GR, Graziano JH: Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study. / Am J Epidemiol 2006, 163:1138鈥?148. CrossRef
42. Agahian B, Lee JS, Nelson JH, Johns RE: Arsenic levels in fingernails as a biological indicator of exposure to arsenic. / Am Ind Hyg Assoc J 1990, 51:646鈥?51. CrossRef
43. Karagas MR, Morris JS, Weiss JE, Spate V, Baskett C, Greenberg ER: Toenail samples as an indicator of drinking water arsenic exposure. / Cancer Epidemiol Biomarkers Prev 1996, 5:849鈥?52.
44. Schmitt MT, Schreinemachers D, Wu K, Ning Z, Zhao B, Le XC, Mumford JL: Human nails as a biomarker of arsenic exposure from well water in Inner Mongolia: comparing atomic fluorescence spectrometry and neutron activation analysis. / Biomarkers 2005, 10:95鈥?04. CrossRef
45. Paakkanen JM, Kurttio P, Paldy A, Pekkanen J: Association between the clastogenic effect in peripheral lymphocytes and human exposure to arsenic through drinking water. / Environ Mol Mutagen 1998, 32:301鈥?13. CrossRef
46. Chen KL, Amarasiriwardena CJ, Christiani DC: Determination of total arsenic concentrations in nails by inductively coupled plasma mass spectrometry. / Biol Trace Elem Res 1999, 67:109鈥?25. CrossRef
47. Thomas DJ: Molecular processes in cellular arsenic metabolism. / Toxicol Appl Pharmacol 2007, 222:365鈥?73. CrossRef
48. Santra A, Chowdhury A, Ghatak S, Biswas A, Krishna DG: Arsenic induces apoptosis in mouse liver is mitochondria dependent and is abrogated by N -acetylcysteine. / Toxicol and Applied Pharm 2007, 220:146鈥?55. CrossRef
49. Buchet JP, Geubel A, Pauwels S, Mahieu P, Lauwerys R: The influence of liver disease on the methylation of arsenite in humans. / Arch Toxicol 1984, 55:151鈥?54. CrossRef
50. Gault AG, Rowland HA, Charnock JM, Wogelius RA, Gomez-Morilla I, Vong S, Leng M, Samreth S, Sampson ML, Polya DA: Arsenic in hair and nails of individuals exposed to arsenic-rich groundwaters in Kandal province, Cambodia. / Sci Total Environ 2008, 393:168鈥?76. CrossRef
51. Ismail IAA, Agha SZA, Ossama Ahmed Shehwan OA: Hematological and Biochemical Studies for Gasoline Toxicity Among Gasoline Workers In Gaza Strip. / J Al-Aqsa Unv 2006, 10.
52. Nilima N, Dongre A, Suryakar N, Patil AJ, Rathi DB: Occupational Lead Exposure In Automobile Workers In North Karnataka (India): Effect On Liver And Kidney Functions. / Al Ame en J Med Sci 2010, 3:284鈥?92.
53. Mora艅ska I, Jurczyk K, Klosinska E, Wi艣niewski K, Karpi艅ska E, Wawrzynowicz-Syczewska M, Urbanowicz W, Rzechu艂a H, Boro艅-Kaczmarska A: Relationship of serum alanine aminotransferase (ALT) to body weight, age and sex in blood donors population. / Wiad Lek 2004, 57:427鈥?30.
54. Middelberg RP, Medland SE, Martin NG, Whitfield JB: A longitudinal genetic study of uric acid and liver enzymes in adolescent twins. / Twin Res Hum Genet 2007, 10:757鈥?64. CrossRef
55. Leclercq I, Horsmans Y, De Bruyere M, Geubel AP: Influence of body mass index, sex and age on serum alanine aminotransferase (ALT) level in healthy blood donors. / Acta Gastroenterol Belg 1999, 62:16鈥?0.
56. Stranges S, Freudenheim JL, Muti P, Farinaro E, Russell M, Nochajski TH, Trevisan M: Differential effect of alcohol drinking pattern on liver enzymes in men and women. / Alcohol Clin Exp Res 2004, 28:949鈥?56. CrossRef
57. Vahter ME: Interactions between Arsenic-Induced Toxicity and Nutrition in Early life. / J Nutr 2007, 137:2798鈥?804.
58. Ferreccio C, Sancha AM: Arsenic exposure and its impact on health in Chile. / J Health Popul Nutr 2006, 24:164鈥?75. - 作者单位：Khairul Islam (1)
Abedul Haque (1)
Rezaul Karim (1) (2)
Abul Fajol (1)
Ekhtear Hossain (1)
Kazi Abdus Salam (1)
Nurshad Ali (1)
Zahangir Alam Saud (1)
Matiar Rahman (1)
Mashiur Rahman (1)
Rezaul Karim (3)
Papia Sultana (4)
Mostaque Hossain (5)
Anwarul Azim Akhand (6)
Abul Mandal (7)
Hideki Miyataka (8)
Seiichiro Himeno (8)
Khaled Hossain (1)
1. Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi, 6205, Bangladesh
2. Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, 7003, Bangladesh
3. FIST, UMP, Gambang, 26300, Pahang, Malaysia
4. Department of Statistics, Rajshahi University, Rajshahi, 6205, Bangladesh
5. Department of Medicine, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh
6. Department of Genetic Engineering and Biotechnology, Dhaka University, Dhaka, 1000, Bangladesh
7. System Biology Research Center, University of Sk枚vde, P. O. Box 408, SE-541-28, Sk枚vde, Sweden
8. Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, 770-8514, Japan
文摘
Background Chronic arsenic exposure has been shown to cause liver damage. However, serum hepatic enzyme activity as recognized on liver function tests (LFTs) showing a dose-response relationship with arsenic exposure has not yet been clearly documented. The aim of our study was to investigate the dose-response relationship between arsenic exposure and major serum enzyme marker activity associated with LFTs in the population living in arsenic-endemic areas in Bangladesh. Methods A total of 200 residents living in arsenic-endemic areas in Bangladesh were selected as study subjects. Arsenic concentrations in the drinking water, hair and nails were measured by Inductively Coupled Plasma Mass Spectroscopy (ICP-MS). The study subjects were stratified into quartile groups as follows, based on concentrations of arsenic in the drinking water, as well as in subjects' hair and nails: lowest, low, medium and high. The serum hepatic enzyme activities of alkaline phosphatase (ALP), aspartate transaminase (AST) and alanine transaminase (ALT) were then assayed. Results Arsenic concentrations in the subjects' hair and nails were positively correlated with arsenic levels in the drinking water. As regards the exposure-response relationship with arsenic in the drinking water, the respective activities of ALP, AST and ALT were found to be significantly increased in the high-exposure groups compared to the lowest-exposure groups before and after adjustments were made for different covariates. With internal exposure markers (arsenic in hair and nails), the ALP, AST and ALT activity profiles assumed a similar shape of dose-response relationship, with very few differences seen in the higher groups compared to the lowest group, most likely due to the temporalities of exposure metrics. Conclusions The present study demonstrated that arsenic concentrations in the drinking water were strongly correlated with arsenic concentrations in the subjects' hair and nails. Further, this study revealed a novel exposure- and dose- response relationship between arsenic exposure metrics and serum hepatic enzyme activity. Elevated serum hepatic enzyme activities in the higher exposure gradients provided new insights into arsenic-induced liver toxicity that might be helpful for the early prognosis of arsenic-induced liver diseases.