Structure and stability of fluoroquinolone-(2-hydroxypropyl)-β-cyclodextrin complexes as perspective antituberculosis drugs

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• 作者：I. M. Deygen ; A. M. Egorov ; E. V. Kudryashova
• 关键词：fluoroquinolones ; cyclodextrin ; host–guest complexes ; IR spectroscopy
• 刊名：Moscow University Chemistry Bulletin
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：71
• 期：1
• 页码：1-6
• 全文大小：436 KB
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• 作者单位：I. M. Deygen (1)
  A. M. Egorov (1) (2)
  E. V. Kudryashova (1)
  
  1. Department of Chemistry, Moscow State University, Moscow, Russia
  2. Russian Medical Academy of Postgraduate Education, the Ministry of Healthcare of the Russian Federation, Moscow, Russia
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Chemistry
  Russian Library of Science
  
• 出版者：Allerton Press, Inc. distributed exclusively by Springer Science+Business Media LLC
• ISSN：1935-0260

文摘

The formation of host–guest complexes of fluoroquinolones (FQs), such as levofloxacin, ofloxacin, and moxifloxacin with (2-hydroxypropyl)-β-cyclodextrin (HP–β–CD) was studied by spectroscopic methods. The stoichiometry and dissociation constants of the inclusion complexes were determined. The formation of complexes of FQs with HP–β–CD was confirmed by the solubility studies, the UV and FTIR spectra and the equilibrium dialysis. The use of the complex of levofloxacin with HP–β–CD leads to the prolonged release of the former observed in the dialysis experiments. The formation of inclusion complexes makes it possible to increase the solubility of FQs by two to five times. The research may provide a basis for the development of new FQ-containing drugs involving HP–β–CD as a nanocarrier system.