β-Glucan exacerbates allergic airway responses to house dust mite allergen
详细信息 查看全文
- 作者：Sabelo Hadebe ; Frank Kirstein ; Kaat Fierens ; Pierre Redelinghuys…
- 关键词：β ; glucans ; Allergy ; Eosinophil ; T helper 2 ; House dust mite
- 刊名：Respiratory Research
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：17
- 期：1
- 全文大小：1,221 KB
- 刊物主题：Pneumology/Respiratory System;
- 出版者：BioMed Central
- ISSN：1465-9921
文摘
β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.