Simultaneous Determination of Ritodrine and Isoxsuprine Using Coupling Technique of Synchronous Fluorimetry and H-Point Standard Addition Method

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• 作者：Dina T. El-Sherbiny ; Dalia R. El-Wasseef ; Mohammed E. Abd El-Ghaffar and Saadia M. El-Ashry
• 关键词：Coupling technique ; Synchronous fluorimetry ; H ; point standard addition method (HPSAM) ; Isoxsuprine HCl ; Ritodrine HCl
• 刊名：Journal of Fluorescence
• 出版年：2010
• 出版时间：January, 2010
• 年：2010
• 卷：20
• 期：1
• 页码：251-260
• 全文大小：490.0 KB

文摘

Simultaneous determination of two structurally related ?₂ adrenergic receptor agonists namely, Ritodrine HCl (RTH) and Isoxsuprine HCl (ISP) was performed using coupling technique of synchronous fluorimetry and H-point standard addition method. Under optimum conditions, linear determination ranges were 1.48 – 14.80 ¡Á 10−6 mol L−1 and 1.54 – 15.44 ¡Á 10−6 mol L−1 for ISP and RTH respectively. RTH and ISP could be determined simultaneously without interference from each other when their concentration ratio varies from 5:1 to 1:5 in the mixed sample. The proposed method was applied to the determination of RTH and ISP in synthetic mixture of pharmaceutical samples, the accuracy and precision of the results were satisfactory.