A4383C and C76G SNP in Cathepsin B is respectively associated with the high risk and tumor size of hepatocarcinoma

详细信息    查看全文

• 作者：Tsung-Po Chen (1) (2)
  Shun-Fa Yang (1) (2)
  Chiao-Wen Lin (3) (4)
  Hsiang-Lin Lee (1) (5)
  Chiung-Man Tsai (1) (6)
  Chia-Jui Weng (7)
  
• 关键词：Cathepsin B ; Diagnostic marker ; Hepatocellular carcinoma ; Single nucleotide polymorphism
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：November 2014
• 年：2014
• 卷：35
• 期：11
• 页码：11193-11198
• 全文大小：154 KB
• 参考文献：1. Shastry BS. SNP alleles in human disease and evolution. J Hum Genet. 2002;47:561鈥?. CrossRef
  2. World Health Organization. The world health report. Geneva: WHO; 2010.
  3. Feitelson MA. Parallel epigenetic and genetic changes in the pathogenesis of hepatitis virus-associated hepatocellular carcinoma. Cancer Lett. 2006;239:10鈥?0. CrossRef
  4. Firpi RJ, Nelson DR. Viral hepatitis: manifestations and management strategy. Hematol Am Soc Hematol Educ Program 2006; 375鈥?0.
  5. Yano Y, Yamashita F, Kuwaki K, et al. Clinical features of hepatitis C virus related hepatocellular carcinoma and their association with alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II. Liver Int. 2006;26:789鈥?5. CrossRef
  6. Hsieh YS, Tsai CM, Yeh CB, et al. Survivin T9809C, an SNP located in 3鈥?UTR, displays a correlation with the risk and clinicopathological development of hepatocellular carcinoma. Ann Surg Oncol. 2012;19:S625鈥?3. CrossRef
  7. Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet. 2002;31:339鈥?6. CrossRef
  8. Weng CJ, Hsieh YH, Tsai CM, et al. Relationship of insulin-like growth factors system gene polymorphisms with the susceptibility and pathological development of hepatocellular carcinoma. Ann Surg Oncol. 2010;17:1808鈥?5. CrossRef
  9. Weng CJ, Tsai CM, Chen YC, et al. Evaluation of the association of urokinase plasminogen activator system gene polymorphisms with susceptibility and pathological development of hepatocellular carcinoma. Ann Surg Oncol. 2010;17:3394鈥?01. CrossRef
  10. Chen TY, Li YC, Liu YF, et al. Role of MMP14 gene polymorphisms in susceptibiliy and pathological development to hepatocellular carcinoma. Ann Surg Oncol. 2011;18:2348鈥?6. CrossRef
  11. Koblinski JE, Ahram M, Sloane BF. Unraveling the role of proteases in cancer. Clin Chim Acta. 2000;291:113鈥?5. CrossRef
  12. Nomura T, Katunuma N. Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells. J Med Investig. 2005;52:1鈥?. CrossRef
  13. Erdem NF, Carlson ER, Gerard DA, Ichiki AT. Characterization of 3 oral squamous cell carcinoma cell lines with different invasion and/or metastatic potentials. J Oral Maxillofac Surg. 2007;65:1725鈥?3. CrossRef
  14. Vigneswaran N, Zhao W, Dassanayake A, et al. Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer. Hum Pathol. 2000;31:931鈥?. CrossRef
  15. Wu W, Tang X, Hu W, et al. Identification and validation of metastasis-associated proteins in head and neck cancer cell lines by two-dimensional electrophoresis and mass spectrometry. Clin Exp Metastasis. 2002;19:319鈥?6. CrossRef
  16. Kawasaki G, Kato Y, Mizuno A. Cathepsin expression in oral squamous cell carcinoma: relationship with clinicopathologic factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;93:446鈥?4. CrossRef
  17. Roshy S, Sloane BF, Moin K. Pericellular cathepsin B and malignant progression. Cancer Metastasis Rev. 2003;22:271鈥?6. CrossRef
  18. Wickramasinghe NS, Nagaraj NS, Vigneswaran N, Zacharias W. Cathepsin B promotes both motility and invasiveness of oral carcinoma cells. Arch Biochem Biophys. 2005;436:187鈥?5. CrossRef
  19. Podgorski I, Sloane BF. Cathepsin B and its role(s) in cancer progression. Biochem Soc Symp. 2003;70:263鈥?6.
  20. Weiss FU, Behn CO, Simon P, et al. Cathepsin B gene polymorphism Val26 is not associated with idiopathic chronic pancreatitis in European patients. Gut. 2007;56:1322鈥?. CrossRef
  21. Stiblar-Martincic D, Hajdinjak T. Polymorphism L26V in the cathepsin B gene may be associated with a risk of prostate cancer and differentiation. J Int Med Res. 2009;37:1604鈥?0. CrossRef
  22. Chen MK, Su SC, Lin CW, et al. Cathepsin B SNPs elevate the pathological development of oral cancer and raise the susceptibility to carcinogen-mediated oral cancer. Hum Genet. 2012;131:1861鈥?. CrossRef
  23. Edge SB, Byrd DR, Compton CC, et al. AJCC cancer staging manual. 7th ed. New York: Springer; 2010.
  24. Chen CJ, Yu MW, Liaw YF. Epidemiological characteristics and risk factors of hepatocellular carcinoma. J Gastroenterol Hepatol. 1997;12:S294鈥?08. CrossRef
  25. Chen TH, Chen CJ, Yen MF, et al. Ultrasound screening and risk factors for death from hepatocellular carcinoma in a high risk group in Taiwan. Int J Cancer. 2002;98:257鈥?1. CrossRef
  26. Tsai MC, Kee KM, Chen YD, et al. Excess mortality of hepatocellular carcinoma and morbidity of liver cirrhosis and hepatitis in HCV-endemic areas in an HBVendemic country: geographic variations among 502 villages in southern Taiwan. J Gastroenterol Hepatol. 2007;22:92鈥?. CrossRef
  27. Akkiz H, Bayram S, Bekar A, et al. G-308A TNF-alpha polymorphism is associated with an increased risk of hepatocellular carcinoma in the Turkish population: case鈥揷ontrol study. Cancer Epidemiol. 2009;33:261鈥?. CrossRef
  28. Chang CC, Chen SC, Hsieh YH, et al. Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma. Clin Chem Lab Med. 2009;47:412鈥?. CrossRef
  29. Buendia MA. Genetics of hepatocellular carcinoma. Semin Cancer Biol. 2000;10:185鈥?00. CrossRef
  30. Keppler D, Sameni M, Moin K, et al. Tumor progression and angiogenesis: cathepsin B & Co. Biochem Cell Biol. 1996;74:799鈥?10. CrossRef
  31. Warwas M, Haczynska H, Gerber J, Nowak M. Cathepsin B-like activity as a serum tumor marker in ovarian carcinoma. Eur J Clin Chem Clin Biochem. 1997;35:301鈥?.
  32. Turk B, Turk D, Turk V. Lysosomal cysteine proteases: more than scavengers. Biochim Biophys Acta. 2000;1477:98鈥?11. CrossRef
  33. Fedorowski A, Steciwko A, Rabczynski J. Serum cathepsin B activity during regression of Morris hepatoma 5123D. Med Sci Monit. 2004;10:BR144鈥?0.
  34. Schwarz KB. Oxidative stress during viral infection: a review. Free Radic Biol Med. 1996;21:641鈥?. CrossRef
  35. Mansouri A, Fromenty B, Berson A, et al. Multiple hepatic mitochondrial DNA deletions suggest premature oxidative aging in alcoholic patients. J Hepatol. 1997;27:96鈥?02. CrossRef
  36. Merican I, Guan R, Amarapuka D, et al. Chronic hepatitis B virus infection in Asian countries. J Gastroenterol Hepatol. 2000;15:1356鈥?1. CrossRef
  37. Lavanchy D. Hepatitis B, virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat. 2004;11:97鈥?07. CrossRef
  38. Wang BE, Ma WM, Sulaiman A, et al. Demographic, clinical, and virological characteristics of hepatocellular carcinoma in Asia: survey of 414 patients from four countries. J Med Virol. 2002;67:394鈥?00. CrossRef
  
• 作者单位：Tsung-Po Chen (1) (2)
  Shun-Fa Yang (1) (2)
  Chiao-Wen Lin (3) (4)
  Hsiang-Lin Lee (1) (5)
  Chiung-Man Tsai (1) (6)
  Chia-Jui Weng (7)
  
  1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
  2. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
  3. Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan
  4. Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan
  5. Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan
  6. Ministry of Health and Welfare, Tainan Hospital, Tainan City, Taiwan
  7. Department of Living Services Industry, Tainan University of Technology, 529 Zhongzheng Rd., Yongkang District, Tainan City, 71002, Taiwan
  
• ISSN：1423-0380

文摘

Single nucleotide polymorphism (SNP) in some genes is a candidate for having or developing a cancer. Cathepsin B (CTSB) is considered to be the biomarker of cancers. The study aimed to evaluate the impacts of three SNPs in CTSB gene on the risk and progress of hepatocellular carcinoma (HCC). The SNPs of CTSB C76G (rs12338), CTSB A4383C (rs13332), and CTSB A8422G (rs8898) from 135 patients with HCC and 520 control participants in Taiwan were determined by real-time PCR. Through analyzing by statistics, we found that the polymorphism of rs13332 was significantly associated to the risk of HCC cancer; a significantly high frequent tumor size development was observed in HCC patients carrying rs12338 polymorphic genotype than those carrying ancestral genotype. The SNPs of rs12338, rs13332, and rs8898 were irrelevant to the frequencies of HCC clinical status and the levels of HCC clinicopathological markers. In conclusions, CTSB A4383C SNP is observed modestly more often in patients who developed HCC than in healthy controls and might be associated with the risk of HCC. The association between CTSB C76G SNP and greater tumor size may warrant further study in regards to the biology of HCC.