The induction of apoptosis and autophagy by Wasabia japonica extract in colon cancer

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• 作者：Shu-Wen Hsuan ; Charng-Cherng Chyau ; Hsiao-Yu Hung…
• 关键词：Apoptosis ; Autophagy ; Colon cancer ; RAD001 ; Wasabia japonica
• 刊名：European Journal of Nutrition
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：55
• 期：2
• 页码：491-503
• 全文大小：1,918 KB
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• 作者单位：Shu-Wen Hsuan (1)
  Charng-Cherng Chyau (2)
  Hsiao-Yu Hung (1)
  Jing-Hsien Chen (3) (5)
  Fen-Pi Chou (1) (4) (5)
  
  1. Institute of Biochemistry and Biotechnology, Medical College, Chung Shan Medical University, Taichung, Taiwan
  2. Research Institute of Biotechnology, Hung Kuang University, Taichung, Taiwan
  3. School of Nutrition, Chung Shan Medical University, Taichung, Taiwan
  5. Chung Shan Medical University, No. 110, Sec. 1, Jiangou N. Rd., South Dist., Taichung City, 402, Taiwan
  4. Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1436-6215

文摘

Purpose Wasabia japonica (wasabi) has been shown to exhibit properties of detoxification, anti-inflammation and the induction of apoptosis in cancer cells. This study aimed to investigate the molecular mechanism of the cytotoxicity of wasabi extract (WE) in colon cancer cells to evaluate the potential of wasabi as a functional food for chemoprevention.