Root canal sealers induce cytotoxicity and necrosis

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• 作者：Tsui-Hsien Huang ; Shinn-Jyh Ding ; Ting-Zen Hsu ; Zen-Dar Lee and Chia-Tze Kao
• 刊名：Journal of Materials Science Materials in Medicine
• 出版年：2004
• 出版时间：2004
• 年：2004
• 卷：15
• 期：7
• 页码：767-771
• 全文大小：160 KB

文摘

There are three types of the root canal sealers commonly used in clinical applications. They are calcium hydroxide base (Sealapex), zinc oxide–eugenol base (Canals), and epoxy-resin base (AH Plus). Elutable substances and degradation products from root canal sealers may gain access to periodontal tissue in a number of ways. The purpose of the present study was to evaluate the biologic effects of the root canal sealers on human oral cancer cell line (OC2). The tetrazolium bromide (MTT) assay was to evaluate the cell's survival rate. The DNA electrophoresis was used to evaluate the OC2 cell's DNA damage. The results demonstrated that the above root canal sealers' survival rates are in dose-dependent increase (p