Phenethyl isothiocyanate enhances TRAIL-induced apoptosis in oral cancer cells and xenografts

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• 作者：Cheng-Chang Yeh ; Hui-Hsin Ko ; Yu-Ping Hsieh ; King-Jean Wu…
• 关键词：Apoptosis ; Death receptors ; Oral cancer ; PEITC ; TRAIL
• 刊名：Clinical Oral Investigations
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：20
• 期：9
• 页码：2343-2352
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Dentistry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1436-3771
• 卷排序：20

文摘

ObjectivesTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been regarded as a promising candidate for cancer therapy. However, most of oral cancer cell lines are resistant to the TRAIL-induced cytotoxicity. The aim of this study was to investigate the ability of phenethyl isothiocyanate (PEITC) to sensitize TRAIL-induced apoptosis in TRAIL-resistant oral cancer cells and xenografts.