Is gastrointestinal dysfunction induced by gastric cancer peritoneal metastasis relevant to impairment of interstitial cells of Cajal?

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• 作者：Hongqun Zheng (1)
  Yan He (2)
  Jinxue Tong (1)
  Lingyu Sun (1)
  Dongdong Yang (1)
  Huaming Li (2)
  Ning Ao (2)
  Xiaoming Jin (2)
  Qifan Zhang (1)
  
• 关键词：Gastric cancer ; Interstitial cells of Cajal ; Mouse model ; Pain ; Peritoneal metastasis
• 刊名：Clinical & Experimental Metastasis
• 出版年：2011
• 出版时间：March 2011
• 年：2011
• 卷：28
• 期：3
• 页码：291-299
• 全文大小：937KB
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• 作者单位：Hongqun Zheng (1)
  Yan He (2)
  Jinxue Tong (1)
  Lingyu Sun (1)
  Dongdong Yang (1)
  Huaming Li (2)
  Ning Ao (2)
  Xiaoming Jin (2)
  Qifan Zhang (1)
  
  1. Department of Oncology, The Fourth Affiliated Hospital of Harbin Medical University, No. 37, Yiyuan Street, Nangang District, Harbin, China
  2. Department of Pathology, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, China
  
• ISSN：1573-7276

文摘

Although impaired gastrointestinal motility from gastric cancer peritoneal metastasis (GCPM) causes extraordinary pain, its cause is unclear. Interstitial cells of Cajal (ICC) are apparently pacemaker cells, and their loss could cause motor dysfunction. In this study, we developed a mouse model for GCPM, and investigated electrophysiological changes in the small intestine and attendant changes in ICC. We found decreased ICC and disrupted electrical rhythm in the model. Pathologic ICC changes were well described. Cancer peritoneal metastasis may impair intestinal myoelectrical activity by damaging ICC and ICC networks. Interstitial cells of Cajal will be a target of palliative treatment and merit further study.