Rapid extraction and purification of lumbrokinase from Lumbricus rubellus using a hollow fiber membrane and size exclusion chromatography

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• 作者：Tingming Fu ; Fengyun Yang ; Huaming Zhu ; Huaxu Zhu ; Liwei Guo
• 关键词：Earthworms ; Hollow fiber membrane ; Fibrinolytic activity ; Lumbrokinase ; Lumbricus rubellus
• 刊名：Biotechnology Letters
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：38
• 期：2
• 页码：251-258
• 全文大小：1,784 KB
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• 作者单位：Tingming Fu (1) (2)
  Fengyun Yang (1)
  Huaming Zhu (1)
  Huaxu Zhu (1)
  Liwei Guo (1)
  
  1. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210029, China
  2. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, 210029, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbiology
  Biotechnology
  Applied Microbiology
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-6776

文摘

Objectives To develop a purification process using hollow fiber membrane separation combined with size exclusion chromatography for the extraction of lumbrokinase from earthworms (Lumbricus rubellus).