Memantine Alleviates Brain Injury and Neurobehavioral Deficits after Experimental Subarachnoid Hemorrhage

详细信息    查看全文

• 作者：Chih-Yuan Huang ; Liang-Chao Wang ; Hao-Kuang Wang ; Chia-Hsin Pan…
• 关键词：Blood–brain barrier ; Memantine ; Neuroprotection ; Nitric oxide synthase ; Subarachnoid hemorrhage
• 刊名：Molecular Neurobiology
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：51
• 期：3
• 页码：1038-1052
• 全文大小：6,934 KB
• 参考文献：1.Macdonald RL, Cusimano MD, Etminan N, Hanggi D, Hasan D, Ilodigwe D, Jaja B, Lantigua H, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Quinn A, Schweizer TA, Schenk T, Spears J, Todd M, Torner J, Vergouwen MD, Wong GK, Collaboration S (2013) Subarachnoid Hemorrhage International Trialists data repository (SAHIT). World Neurosurg 79(3-):418-22View Article PubMed
  2.King JT Jr (1997) Epidemiology of aneurysmal subarachnoid hemorrhage. Neuroimaging Clin N Am 7(4):659-68PubMed
  3.Cahill J, Calvert JW, Zhang JH (2006) Mechanisms of early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab 26(11):1341-353View Article PubMed
  4.Sarrafzadeh A, Haux D, Kuchler I, Lanksch WR, Unterberg AW (2004) Poor-grade aneurysmal subarachnoid hemorrhage: relationship of cerebral metabolism to outcome. J Neurosurg 100(3):400-06View Article PubMed
  5.Hillered L, Vespa PM, Hovda DA (2005) Translational neurochemical research in acute human brain injury: the current status and potential future for cerebral microdialysis. J Neurotrauma 22(1):3-1View Article PubMed
  6.Arundine M, Tymianski M (2003) Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium 34(4-):325-37View Article PubMed
  7.Schulz MK, Wang LP, Tange M, Bjerre P (2000) Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg 93(5):808-14View Article PubMed
  8.Park S, Yamaguchi M, Zhou C, Calvert JW, Tang J, Zhang JH (2004) Neurovascular protection reduces early brain injury after subarachnoid hemorrhage. Stroke 35(10):2412-417View Article PubMed
  9.Sehba FA, Chereshnev I, Maayani S, Friedrich V Jr, Bederson JB (2004) Nitric oxide synthase in acute alteration of nitric oxide levels after subarachnoid hemorrhage. Neurosurgery 55(3):671-77, discussion 677-78View Article PubMed
  10.Dawson VL, Kizushi VM, Huang PL, Snyder SH, Dawson TM (1996) Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. J Neurosci 16(8):2479-487PubMed
  11.Rammes G, Danysz W, Parsons CG (2008) Pharmacodynamics of memantine: an update. Curr Neuropharmacol 6(1):55-8View Article PubMed Central PubMed
  12.Chen HS, Wang YF, Rayudu PV, Edgecomb P, Neill JC, Segal MM, Lipton SA, Jensen FE (1998) Neuroprotective concentrations of the N-methyl-d -aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience 86(4):1121-132View Article PubMed
  13.Parsons CG, Danysz W, Quack G (1999) Memantine is a clinically well tolerated N-methyl-d -aspartate (NMDA) receptor antagonist—a review of preclinical data. Neuropharmacology 38(6):735-67View Article PubMed
  14.Ehrlich M, Knolle E, Ciovica R, Bock P, Turkof E, Grabenwoger M, Cartes-Zumelzu F, Kocher A, Pockberger H, Fang WC, Wolner E, Havel M (1999) Memantine for prevention of spinal cord injury in a rabbit model. J Thorac Cardiovasc Surg 117(2):285-91View Article PubMed
  15.Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, van der Worp HB, Traystman R, Minematsu K, Donnan GA, Howells DW (2009) Good laboratory practice: preventing introduction of bias at the bench. Stroke 40(3):e50–e52View Article PubMed
  16.Bederson JB, Germano IM, Guarino L (1995) Cortical blood flow and cerebral perfusion pressure in a new noncraniotomy model of subarachnoid hemorrhage in the rat. Stroke 26(6):1086-091, discussion 1091-082View Article PubMed
  17.Thal SC, Sporer S, Klopotowski M, Thal SE, Woitzik J, Schmid-Elsaesser R, Plesnila N, Zausinger S (2009) Brain edema formation and neurological impairment after subarachnoid hemorrhage in rats. Laboratory investigation. J Neurosurg 111(5):988-94View Article PubMed
  18.Sugawara T, Ayer R, Jadhav V, Zhang JH (2008) A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. J Neurosci Methods 167(2):327-34View Article PubMed Central PubMed
  19.Takata K, Sheng H, Borel CO, Laskowitz DT, Warner DS, Lombard FW (2009) Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage. J Neurosurg Anesthesiol 21(4):326-33View Article PubMed
  20.Silasi G, Colbourne F (2009) Long-term assessment of motor and cognitive behaviours in the intraluminal perforation model of subarachnoid hemorrhage in rats. Behav Brain Res 198(2):380-87View Article PubMed
  21.Germano A, Caffo M, Angileri FF, Arcadi F, Newcomb-Fernandez J, Caruso G, Meli F, Pineda JA, Lewis SB, Wang KK, Bramanti P, Costa C, Hayes RL (2007) NMDA receptor antagonist felbamate reduces behavioral deficits and blood–brain barrier permeability changes after experimental subarachnoid hemorrhage in the rat. J Neurotrauma 24(4):732-44View Article PubMed
  22.Lin KY, Cherng C
• 作者单位：Chih-Yuan Huang (1) (2)
  Liang-Chao Wang (1) (2)
  Hao-Kuang Wang (1) (3)
  Chia-Hsin Pan (1)
  Ya-Yun Cheng (1)
  Yan-Shen Shan (1) (2)
  Chung-Ching Chio (1) (4)
  Kuen-Jer Tsai (1) (5)
  
  1. Institute of Clinical Medicine, National Cheng Kung University, Tainan, 704, Taiwan
  2. Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan
  3. Department of Neurosurgery, E-Da Hospital, Kaohsiung, Taiwan
  4. Department of Neurosurgery, Chi Mei Medical Center, Tainan, Taiwan
  5. Center of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
  
• 刊物主题：Neurosciences; Neurobiology; Cell Biology; Neurology;
• 出版者：Springer US
• ISSN：1559-1182

文摘

Subarachnoid hemorrhage (SAH) causes brain injury via glutamate excitotoxicity, which leads to an excessive Ca2+ influx and this starts an apoptotic cascade. Memantine has been proven to reduce brain injury in several types of brain insults. This study investigated the neuro-protective potential of memantine after SAH and explored the underlying mechanisms. An endovascular perforation rat model of SAH was used and Sprague–Dawley rats were randomized into sham surgery, SAH-?vehicle, and SAH-?memantine groups. The effects of memantine on SAH were evaluated by assessing the neuro-behavioral functions, blood–brain barrier (BBB) permeability and neuronal cell preservation. The mechanisms of action of memantine, with its N-methyl-d-aspartate (NMDA) antagonistic characteristics on nitric oxide synthase (NOS) expression and peroxynitrite formation, were also investigated. The apoptotic cascade after SAH was suppressed by memantine. Neuronal NOS (nNOS) expression, peroxynitrite formation, and subsequent oxidative/nitrosative stress were also reduced. Memantine effectively preserved BBB integrity, rescued neuronal injury, and improved neurological outcome in experimental SAH. Memantine has neuro-protective potential in experimental SAH and may help combat SAH-induced brain damage in the future.