Knockdown of zebrafish YY1a can downregulate the phosphatidylserine (PS) receptor expression, leading to induce the abnormal brain and heart development
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- 作者：Wei-Lun Shiu ; Kuan-Rong Huang ; Jo-Chi Hung ; Jen-Leih Wu…
- 关键词：YY1a ; Phosphatidylserine receptor ; Zebrafish ; Knockdown ; Brain ; Heart
- 刊名：Journal of Biomedical Science
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：23
- 期：1
- 全文大小：2,388 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Biomedicine - 出版者：Springer Netherlands
- ISSN：1423-0127
文摘
Background Yin Yang 1 (YY1) is a ubiquitously expressed GLI-Kruppel zinc finger-containing transcriptional regulator. YY1 plays a fundamental role in normal biologic processes such as embryogenesis, differentiation, and cellular proliferation. YY1 effects on the genes involved in these processes are mediated via initiation, activation, or repression of transcription depending upon the context in which it binds. The role of the multifunctional transcription factor Yin Yang 1 (YY1) in tissue development is poorly understood. In the present, we investigated YY1a role in developing zebrafish on PSR-mediated apoptotic cell engulfment during organic morphogenesis.