Natural rules for Arabidopsis thaliana pre-mRNA splicing site selection

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• 作者：Ning Wu (1)
  Kanyand Matand (1) (2)
  Huijuan Wu (3)
  Baoming Li (3)
  Kayla Love (4)
  Brittany Stoutermire (3)
  Yanfeng Wu (2)
  
• 关键词：Arabidopsis thaliana ; Pre ; mRNA splicing
• 刊名：Central European Journal of Biology
• 出版年：2012
• 出版时间：August 2012
• 年：2012
• 卷：7
• 期：4
• 页码：620-625
• 全文大小：447KB
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• 作者单位：Ning Wu (1)
  Kanyand Matand (1) (2)
  Huijuan Wu (3)
  Baoming Li (3)
  Kayla Love (4)
  Brittany Stoutermire (3)
  Yanfeng Wu (2)
  
  1. Center for Biotechnology Research and Education, Langston University, Langston, Oklahoma, 73050, USA
  2. Department of Biology, School of Arts and Science, Langston University, Langston, Oklahoma, 73050, USA
  3. Department of Biology, Beijing Center for Physical and Chemical Analysis, 100089, Beijing, China
  4. Department of Chemistry, School of Arts and Science, Langston University, Langston, Oklahoma, 73050, USA
  
• ISSN：1644-3632

文摘

The accurate prediction of plant pre-mRNA splicing sites has been studied extensively. The rules for plant pre-mRNA splicing still remain unknown. This study, based on confirmed sequence data, systematically analyzed all expressed genes on Arabidopsis thaliana chromosome IV to quantitatively explore the natural splicing rules. The results indicated that defining Arabidopsis thaliana pre-mRNA splicing sites required a combination of multiple factors including (1) relative conserved consensus sequence at splicing site; (2) individual nucleotide distribution pattern in 50 nucleotides up- and down-stream regions of splicing site; (3) quantitative analysis of individual nucleotide distribution by using the formulations concluded from this study. The combination of all these factors together can bring the accuracy of Arabidopsis thaliana splicing site recognition over 99%. The results provide additional information to the future of plant pre-mRNA splicing research.