Computer prediction of paratope on antithrombotic antibody 10B12 and epitope on platelet glycoprotein VI via molecular dynamics simulation
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- 作者：Wenping Liu ; Guangjian Liu ; Huiyun Zhou ; Xiang Fang…
- 关键词：10B12/GPVI interaction ; Homology modeling ; Molecular dynamics ; Key residue analysis
- 刊名：BioMedical Engineering OnLine
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：15
- 期：2-supp
- 全文大小：975KB
- 刊物类别：Engineering
- 刊物主题：Biomedical Engineering; Biomaterials; Biotechnology; Biomedical Engineering/Biotechnology;
- 出版者：BioMed Central
- ISSN：1475-925X
- 卷排序：15
文摘
BackgroundInteraction between immunoglobulin-like receptor glycoprotein VI (GPVI) and collagen plays a central role in platelet activation and sequent firm adhesion. Of various antithrombotic agents targeting GPVI, antibody 10B12 is of great potential to block the GPVI-collagen interaction, but less is known about 10B12 paratope and GPVI epitope.