Skin manifestations of Kikuchi-Fujimoto disease: case report and review

详细信息    查看全文

• 作者：Hung-Rong Yen (A1)
  Pen-Yi Lin (A1)
  Wen-Yu Chuang (A2)
  Min-Lin Chang (A3)
  Cheng-Hsun Chiu (A1)
  
• 关键词：Histiocytic necrotising lymphadenitis ; Kikuchi ; Fujimoto disease ; Lupus erythematosus
• 刊名：European Journal of Pediatrics
• 出版年：2004
• 出版时间：April 2004
• 年：2004
• 卷：163
• 期：4-5
• 页码：210-213
• 全文大小：365KB
• 参考文献：1. Dorfman RF, Berry GJ (1988) Kikuchi鈥檚 histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn Pathol 5: 329鈥?45
  2. Eisner MD, Amory J, Mullaney B, Tierney L Jr, Browner WS (1996) Necrotizing lymphadenitis associated with systemic lupus erythematosus. Semin Arthritis Rheum 26: 477鈥?82
  3. El-Ramahi KM, Karrar A, Ali MA (1994) Kikuchi disease and its association with systemic lupus erythematosus. Lupus 3: 409鈥?11
  4. Fujimoto Y, Kojima Y, Yamaguchi K (1972) Cervical subacute necrotizing lymphadenitis. Naika 30: 920鈥?27
  5. Kaur S, Thami GP, Mohan H, Kanwar AJ (2001) Kikuchi disease with facial rash and erythema multiforme. Pediatr Dermatol 18: 403鈥?05 CrossRef
  6. Kaur S, Thami GP, Kanwar AJ (2002) Kikuchi鈥檚 disease, skin and systemic lupus erythematosus. Br J Dermatol 146: 167鈥?68 CrossRef
  7. Kikuchi M (1972) Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytes. Acta Hematol Jpn 35: 379鈥?80
  8. Kim KJ, Jee MS, Chang SE, Choi JH, Sung KJ, Moon KC, Koh JK (2003) Kikuchi-Fujimoto disease with papulopustular skin manifestations. Clin Exp Dermatol 28: 142鈥?44
  9. Kuo TT (1990) Cutaneous manifestation of Kikuchi鈥檚 histiocytic necrotizing lymphadenitis. Am J Surg Pathol 14: 872鈥?76
  10. Kuo TT (1995) Kikuchi鈥檚 disease (histiocytic necrotizing lymphadenitis): a clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology, and DNA ploidy. Am J Surg Pathol 19: 798鈥?09
  11. Lien CH, Yang W, Tsai YC, Huang PH (1999) Kikuchi鈥檚 disease (histiocytic necrotizing lymphadenitis): report of one case. Acta Paediatr Taiwan 40: 344鈥?47
  12. Lopez C, Oliver M, Olavarria R, Sarabia MA, Chopite M (2000) Kikuchi-Fujimoto necrotizing lymphadenitis associated with cutaneous lupus erythematosus. Am J Dermatopathol 22: 328鈥?33
  13. Menasce LP, Banerjee SS, Edmondson D, Harris M (1998) Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease): continuing diagnostic difficulties. Histopathology 33: 248鈥?54 CrossRef
  14. Pileri S, Kikuchi M, Helbron D, Lennert K (1982) Histiocytic necrotizing lymphadenitis without granulocytic infiltration. Virchows Arch A Pathol Pathol Anat 395: 257鈥?71
  15. Spies J, Foucar K, Thompson CT, Le Boit PE (1999) The histopathology of cutaneous lesions of Kikuchi鈥檚 disease (necrotizing lymphadenitis): a report of 5 cases. Am J Surg Pathol 23: 1040鈥?047 CrossRef
  16. Tsang WYW, Chan JKC, Ng CS (1994) Kikuchi鈥檚 lymphadenitis: a morphologic analysis of 75 cases with special reference to unusual features. Am J Surg Pathol 18: 219鈥?31
  17. Yang CH, Young TG, Peng MY, Lee HS (1995) Cutaneous manifestation of Kikuchi鈥檚 disease: a case report. Zhonghua Yi Xue Za Zhi (Taipei) 55: 472鈥?75
  18. Yasukawa K, Matsumura T, Sato-Matsumura KC, Takahashi T, Fujioka Y, Kobayashi H, Shimizu H (2001) Kikuchi鈥檚 disease and the skin: case report and review of the literature. Br J Dermatol 144: 885鈥?89 CrossRef
  
• 作者单位：Hung-Rong Yen (A1)
  Pen-Yi Lin (A1)
  Wen-Yu Chuang (A2)
  Min-Lin Chang (A3)
  Cheng-Hsun Chiu (A1)
  
  A1. Division of Paediatric Infectious Diseases, Department of Paediatrics, Chang Gung Children鈥檚 Hospital, 5 Fu-Shin Street, Kweishan, 333, Taoyuan, Taiwan
  A2. Department of Pathology, Chang-Gung Memorial Hospital, Taoyuan, Taiwan
  A3. Department of Anatomy and Cell Biology, National Taiwan University, Taiwan
  

文摘

Kikuchi-Fujimoto disease (KFD) is a histiocytic necrotising lymphadenitis, which is a benign disease of unknown aetiology. Misdiagnosing KFD as lymphoma or systemic lupus erythematosus is not uncommon due to the similarity of clinical and histopathological features of these diseases. A 12-year-old female suffered from cervical lymphadenopathy, leukocytopenia, fever and especially skin rash. The biopsy of the lymph node was compatible with KFD. The skin biopsy showed interface alterations with vacuolar degeneration of the basal cells suggesting lupus erythematosus; however, the patient did not fulfill the diagnostic criteria for systemic lupus erythematosus. After treatment with acetaminophen, fever subsided and the skin rashes disappeared without relapse during a 10-month follow-up period. Conclusion: the histopathological findings of cutaneous lesions in KFD are usually similar to those observed in the involved lymph nodes. This report suggests that interface change might be one of the pathological features of the cutaneous manifestations of KFD.