Plasma serotonin levels are elevated in pregnant women with hyperemesis gravidarum

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• 作者：Huseyin Cengiz ; Hediye Dagdeviren…
• 关键词：Hyperemesis gravidarum ; Serotonin ; Ondansetron ; Pathogenesis ; Thyroid hormones
• 刊名：Archives of Gynecology and Obstetrics
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：291
• 期：6
• 页码：1271-1276
• 全文大小：353 KB
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• 作者单位：Huseyin Cengiz (1)
  Hediye Dagdeviren (1)
  Sema Suzen Caypinar (1)
  Ammar Kanawati (1)
  Sukru Yildiz (1)
  Murat Ekin (1)
  
  1. Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Tevfik Saglam Street, No: 11, Zuhuratbaba, Istanbul, Bakirkoy, Turkey
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gynecology
  Obstetrics and Perinatology
  Endocrinology
  Human Genetics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0711

文摘

Purpose This study aimed to determine the association between serotonin and hyperemesis gravidarum. Materials and methods Plasma samples of 87 women in their first trimester pregnancies with HG (n?=?28), morning sickness of pregnancy (n?=?30) and control (n?=?29) groups were obtained. Plasma levels of serotonin were compared between the groups, and the correlations with severity of symptoms using modified PUQE (Pregnancy Unique Quantification of Emesis) scoring, BMI, E2, hCG and TSH were calculated. Results When the groups were compared with respect to serotonin levels, the group with hyperemesis gravidarum was found to have significantly higher serotonin levels (p?=?0.001). A significant positive correlation was found between the serotonin level and the PUQE score in all study subjects (r?=?0.578, p?=?0.0001). A serotonin threshold of >277.58?ng/mL had a sensitivity of 75?%, specificity of 86.4?%, positive predictive value of 72.4?%, negative predictive value of 87.9?%, and a likelihood ratio of 5.53 (p?=?0.0001). Conclusions Our findings support the possible role of serotonin in the pathogenesis of hyperemesis gravidarum.