Chromosome 9p21 rs10757278 polymorphism is associated with the risk of metabolic syndrome

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• 作者：Burcu Bayoglu (1)
  Huseyin Altug Cakmak (2)
  Husniye Yuksel (2)
  Gunay Can (3)
  Bilgehan Karadag (2)
  Turgut Ulutin (1)
  Vural Ali Vural (2)
  Mujgan Cengiz (1)
  
• 关键词：Metabolic syndrome ; Chromosome 9p21 ; Genetic variation ; Haplotype
• 刊名：Molecular and Cellular Biochemistry
• 出版年：2013
• 出版时间：2 - July 2013
• 年：2013
• 卷：379
• 期：1
• 页码：77-85
• 全文大小：229KB
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  37. Bayoglu B, Cengiz M, Cakmak HA, Uysal O, Yuksel H (2011) Association of a Common Variant on Chromosome 9p21 in Turkish Patients with Metabolic Syndrome. IV.International Congress of Molecular Medicine, p 61-2, 27-0 June 2011, Istanbul, Turkey
  
• 作者单位：Burcu Bayoglu (1)
  Huseyin Altug Cakmak (2)
  Husniye Yuksel (2)
  Gunay Can (3)
  Bilgehan Karadag (2)
  Turgut Ulutin (1)
  Vural Ali Vural (2)
  Mujgan Cengiz (1)
  
  1. Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, 34098, Cerrahpasa Fatih/Istanbul, Turkey
  2. Department of Cardiology, Cerrahpasa Medical Faculty, Istanbul University, Cerrahpasa Fatih/Istanbul, Turkey
  3. Department of Public Health, Cerrahpasa Medical Faculty, Istanbul University, Cerrahpasa Fatih/Istanbul, Turkey
  
• ISSN：1573-4919

文摘

Metabolic syndrome (MetS) is a common multifactorial disorder that involves abdominal obesity, dyslipidemia, hypertension, and hyperglycemia. Genome-wide association studies have identified a major risk locus for coronary artery disease and myocardial infarction on chromosome 9p21. Here, we examined the frequency of single nucleotide polymorphisms (SNPs) on chromosome 9p21 in a sample of Turkish patients with MetS and further investigated the correlation between regional SNPs, haplotypes, and MetS. The real-time polymerase chain reaction (RT-PCR) was used to analyze 4 SNPs (rs10757274 A/G, rs2383207 A/G, rs10757278 A/G, rs1333049 C/G) in 291 MetS patients and 247 controls. Analysis of 4 SNPs revealed a significant difference in the genotype distribution for rs2383207, rs10757278, and rs1333049 between MetS patients and controls (p?=?0.041, p?=?0.005, p?=?0.023, respectively) but not for rs10757274 (p?=?0.211). MetS and control allelic frequencies for rs2383207, rs10757278, and rs1333049 were statistically different (p?<?0.05). The rs2383207 AG variant, was identified as a MetS risk factor (p?=?0.012, OR?=?33.271; 95?% CI: 2.193-04.805) and the AA haplotype in block 1 and the GC, AG haplotypes in block 2 were associated with MetS (χ 2?=?3.875, p?=?0.049; χ 2?=?9.334, p?=?0.0022; χ 2?=?9.134, p?=?0.0025, respectively). In this study, we found that chromosome 9p21 SNP rs10757278 and related haplotypes correlate with MetS risk. This is the first report showing an association between a 9p21 variant and MetS and suggests that rs10757278 polymorphism may confer increased risk for disease.