Synthesis of diverse pyrazole-4-sulfonyl chlorides starting from 2-(benzylthio)malonaldehyde
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- 作者：Pavlo A. Sokolyuk ; Ivan S. Kondratov ; Olexiy V. Gavrylenko…
- 关键词：Heterocycles ; Pyrazole ; Sulfonyl chlorides ; Sulfonamides ; Oxidation ; Chlorination ; Cyclization ; Hydrazines
- 刊名：Molecular Diversity
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：20
- 期：1
- 页码：1-7
- 全文大小：1,029 KB
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Ivan S. Kondratov (2) (3)
Olexiy V. Gavrylenko (1) (2)
Andrey A. Tolmachov (1) (2)
1. Kyiv National Taras Shevchenko University, 64 Volodymirska st., Kyiv, 33, 01033, Ukraine
2. Enamine Ltd., 23 A. Matrosova st., Kyiv, 01103, Ukraine
3. Institute of Bioorganic Chemistry and Petrochemistry, National Ukrainian Academy of Science, Murmanska 1, Kyiv, 94, 02660, Ukraine - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Analytical Chemistry
Polymer Sciences
Organic Chemistry
Pharmacy - 出版者：Springer Netherlands
- ISSN：1573-501X
文摘
A series of pyrazole-4-sulfonyl chlorides was obtained by a convenient 2-step method starting from synthetically available 2-(benzylthio)malonaldehyde. The method can be applied for the effective multi-gram synthesis of diverse pyrazole-containing sulfonyl chlorides which are mostly not available by other methods. Keywords Heterocycles Pyrazole Sulfonyl chlorides Sulfonamides Oxidation Chlorination Cyclization Hydrazines