Chemical constituents of Piper aduncum and their inhibitory effects on soluble epoxide hydrolase and tyrosinase

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• 作者：Bui Thi Thuy Luyen ; Nguyen Phuong Thao ; Wahyu Widowati…
• 关键词：Piper aduncum ; Alkyl glycoside ; Soluble epoxide hydrolase ; Tyrosinase inhibition
• 刊名：Medicinal Chemistry Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：26
• 期：1
• 页码：220-226
• 全文大小：
• 刊物主题：Pharmacology/Toxicology; Biochemistry, general; Cell Biology;
• 出版者：Springer US
• ISSN：1554-8120
• 卷排序：26

文摘

A new compound, 2(S)-isobutanol 2-O-β-d-arabinopyranosyl(1→6)-O-β-d-glucopyranoside (1), along with ten known compounds (2–11) were isolated from Piper aduncum L. leaves. The effects of these compounds on soluble epoxide hydrolase and tyrosinase inhibition were evaluated. Among them, compounds 3, 8, and 9 exhibited significant tyrosinase inhibitory activity with IC₅₀ values of 39.3 ± 1.8, 41.3 ± 2.2, and 37.5 ± 2.7 µM, respectively. However, the effects of isolated compounds on soluble epoxide hydrolase inhibition were weak or absent, and compounds 4 and 11 showed the highest inhibitory activity with values of 61.2 ± 4.3 and 60.6 ± 3.7 % at a concentration of 100 μM.