Clinical practice. Diagnosis and treatment of cow’s milk allergy
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- 作者：C. M. Frank Kneepkens (1)
Yolanda Meijer (2) - 关键词：Cow’s milk allergy ; Double ; blind placebo ; controlled food challenge ; DBPCFC ; Hypoallergenic formula
- 刊名：European Journal of Pediatrics
- 出版年：2009
- 出版时间：August 2009
- 年：2009
- 卷：168
- 期：8
- 页码：891-896
- 全文大小：143KB
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Yolanda Meijer (2)
1. Department of Paediatrics, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
2. Centre for Paediatric Allergology, Wilhelmina Children’s Hospital, University Medical Centre, Utrecht, The Netherlands
文摘
Introduction Cow’s milk allergy (CMA) is thought to affect 2-% of infants. The signs and symptoms are nonspecific and may be difficult to objectify, and as the diagnosis requires cow’s milk elimination followed by challenge, often, children are considered cow’s milk allergic without proven diagnosis. Diagnosis Because of the consequences, a correct diagnosis of CMA is pivotal. Open challenges tend to overestimate the number of children with CMA. The only reliable way to diagnose CMA is by double-blind, placebo-controlled challenge (DBPCFC). Therapy At present, the only proven treatment consists of elimination of cow’s milk protein from the child’s diet and the introduction of formulas based on extensively hydrolysed whey protein or casein; amino acid-based formula is rarely indicated. The majority of children will regain tolerance to cow’s milk within the first 5?years of life. Conclusions Open challenges can be used to reject CMA, but for adequate diagnosis, DBPCFC is mandatory. In most children, CMA can be adequately treated with extensively hydrolysed whey protein or casein formulas.