Posterior Urethral Valves

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• 作者：Irina Stanasel ; Edmond Gonzales
• 关键词：Posterior urethral valves ; Hydronephrosis ; Lower urinary tract obstruction ; Fetal intervention ; Pediatric renal transplant
• 刊名：Current Bladder Dysfunction Reports
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：10
• 期：3
• 页码：250-255
• 全文大小：331 KB
• 参考文献：Papers of particular interest, published recently, have been highlighted as: 鈥?Of importance 鈥⑩€?Of major importance1.鈥?/div>Krishnan A, de Souza A, Konijeti R, Baskin LS. The anatomy and embryology of posterior urethral valves. J Urol. 2006;175:1214鈥?0. Excellent explanation of anatomy and embryology of posterior urethral valves.CrossRef PubMed
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  7.Chaumoitre K, Merrot T, Petit P, Sayegh-Martin Y, Alessandrini P, Panuel M. Voiding cystourethrography in boys. Does the presence of the catheter during voiding alter the evaluation of the urethra? J Urol. 2004;171(3):1280鈥?.CrossRef PubMed
  8.Harvie S, McLeod L, Acott P, Walsh E, Abdolell M, Macken MB. Abnormal antenatal sonogram: an indicator of disease severity in children with posterior urethral valves. Can Assoc Radiol J. 2009;60(4):185鈥?.CrossRef PubMed
  9.Bernardes LS, Akses G, Saada J, Masse V, Elie C, Dumez Y, et al. Keyhole sign: how specific is it for the diagnosis of posterior urethral valves? Ultrasound Obstet Gynecol. 2009;34(4):419鈥?3.CrossRef PubMed
  10.Harrison MR, Nakayama DK, Noall RA, de Lorimier A. Correction of congenital hydronephrosis in utero II. Decompression reverses the effects of obstruction on the fetal lung and urinary tract. J Pediatr Surg. 1982;17:965鈥?4.CrossRef PubMed
  11.鈥?/div>Quintero R, Shukla A, Homsy Y, Bukkapatnam R. Successful in utero endoscopic ablation of posterior urethral valves: a new dimension in fetal urology. Urology. 2000;55(5):774. Case report detailed successful fetal ablation of posterior urethral valves.
  12.Sananes N, Favre R, Koh CJ, Zaloszyc A, Braun MC, Roth DR, Moog R, Becmeur F, Belfort MA, Ruano R. Urological fistulas after cystoscopic laser ablation of posterior urethral valves鈥搒urgical technical aspects. Ultrasound Obstet Gynecol. 2015;45(2):183鈥?.
  13.Morris RK, Quinlan-Jones E, Kilby MD, Khan KS. Systematic review of accuracy of fetal urine analysis to predict poor postnatal renal function in cases of congenital urinary tract obstruction. Prenat Diagn. 2007;27(10):900鈥?1.CrossRef PubMed
  14.Bernardes LS, Aksnes G, Saada J, Masse V, Elie C, Dumez Y, et al. Keyhole sign: how specific is it for the diagnosis of posterior urethral valves? J Pediatr Surg. 2011;46(7):1412鈥?.CrossRef PubMed
  15.Klein J, Lacroix C, Caubet C, Siwy J, Zurbig P, Dakna M, et al. Fetal urinary peptides to predict postnatal outcome of renal disease in fetuses with posterior urethral valves. Sci Transl Med. 2013;5:198ra106.CrossRef PubMed
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  19.Mokhless I, Zahran A, Saad A, Yehira M, Youssif M. Effect of botox injection at the bladder neck in boys with bladder dysfunction after valve ablation. J Pediatr Urol. 2014;10:899鈥?05.CrossRef PubMed
  20.Gupta RK, Shah HS, Jadhav V et al. Urethral ratio on voiding cystourethrogram: a comparative method to assess success of posterior urethral valve ablation. J Pediatr Urol. 2010;6(1):32鈥?.
  21.Pohl M, Mentzel HJ, Vogt S, Walther M, Ronnefarth G, John U. Risk factors for renal insufficiency in children with urethral valves. Pediatr Nephrol. 2012;27(3):443鈥?0.CrossRef PubMed
  22.Ansari MS, Gulia A, Srivastava A, Kapoor R. Risk factors for progression to end stage renal disease in children with posterior urethral valves. J Pediatr Urol. 2010;6(3):261鈥?.CrossRef PubMed
  23.Sarhan O, El-Dahshan K, Sarhan M. Prognostic value of serum creatinine levels in children with posterior urethral valves treated by primary valve ablation. J Pediatr Urol. 2010;6(1):11鈥?.CrossRef PubMed
  24.Ghanem MA, Wolffenbuttel KP, De Vylder A, Nijman RJ. Long-term bladder dysfunction and renal function in boys with posterior urethral valves based on urodynamic findings. J Urol. 2004;171:2409鈥?2.CrossRef PubMed
  25.Peters CA, Bolkier M, Bauer SB, Hendren WH, Colodny AH, Mandell J, et al. The urodynamic consequences of posterior urethral valves. J Urol. 1990;144:122鈥?.PubMed
  26.Sarhan O, Zaccaria I, Macher MA, Muller F, Vuillard E, Delezoide AL, et al. Long term outcome of prenatally detected posterior urethral valves: single center study of 65 cases managed by primary valve ablation. J Urol. 2008;179(1):307鈥?2.CrossRef PubMed
  27.Ghane S, Bitzan M, Szymanski K, Bell LE, Gupta I, Tchervenkov J, et al. Native nephrectomy prior to pediatric kidney transplantation: biological and clinical aspects. Pediatr Nephrol. 2012;27(7):1179鈥?8.CrossRef
  28.Otukesh H, Basiri A, Simfroosh N, et al. Kidney transplantation in children with posterior urethral valves. Pediatr Transplant. 2008;12(5):516鈥?.CrossRef PubMed
  
• 作者单位：Irina Stanasel (1)
  Edmond Gonzales (1)
  
  1. Texas Children鈥檚 Hospital/Baylor College of Medicine, Clinical Care Center, 6701 Fannin Street Suite 620, Houston, TX, 77030, USA
  
• 刊物主题：Urology/Andrology;
• 出版者：Springer US
• ISSN：1931-7220

文摘

Posterior urethral valves (PUV) are the most common cause of lower urinary tract obstruction in male infants. Due to improved technique and availability of prenatal imaging, diagnosis is typically suspected prenatally and confirmed postnatally. Prenatal intervention is performed in select centers with vesicoamniotic shunting or with fetal cystoscopy and antegrade ablation of the PUV when detected. Prenatal intervention has been associated with an improvement in neonatal survival; however, evidence that renal function is indeed improved remains scant. The mainstay of treatment remains early diagnosis with early establishment of drainage and subsequent management of bladder dysfunction with behavioral therapy, medication, clean intermittent catheterization, and occasionally with bladder augmentation. Other measures such as nephrectomy can be implemented to manage polyuria. Ultimately, 30 % of patients born with PUV develop end-stage renal disease and require renal transplantation. Keywords Posterior urethral valves Hydronephrosis Lower urinary tract obstruction Fetal intervention Pediatric renal transplant