In vitro anticancer and antibacterial activities of octahedral ruthenium(III) complexes with hydroxamic acids. Synthesis and spectroscopic characterization
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- 作者：Raj Kaushal ; Sheetal
- 关键词：Ruthenium complexes ; hydroxamic acids ; antibacterial and anticancer activity
- 刊名：Russian Journal of General Chemistry
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：86
- 期：2
- 页码：360-367
- 全文大小：248 KB
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Sheetal (1)
1. Department of Chemistry, National Institute of Technology, Hamirpur, Himachal Pradesh, 177005, India - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Chemistry
Russian Library of Science - 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
- ISSN：1608-3350
文摘
Five new ruthenium(III) complexes of the general formulas [RuCl(H2O)L2] (1–4) and [RuCl3(H2O)(HL)2] (5), where L = benzohydroximato (1), salicylhydroximato (2), acetohydroximato (3), hydroxyureato (4), LH = N-hydroxy-N-phenylbenzamide (5), were synthesized by reaction of RuCl3 · 3H2O with the corresponding hydroxamic acids at a molar ratio of 1: 2 molar. The complexes were characterized by elemental analyses and FT-IR, UV-Vis, 1H and 13C NMR, and mass spectra. The complexes showed higher antibacterial activity against ten pathogenic bacterial strains than the corresponding ligands. The anticancer activity of the complexes against IMR-32 (neuroblastoma) cancer and CHO (Chinese hamster ovary) normal cell lines was evaluated using MTT assay with respect to camptothecin as control. Complex 5 was found to exhibit an appreciable cytotoxicity against IMR-32 cell line with an IC50 value of 102.27 μM.