The effect of ascorbic acid on the efficiency of cytotoxic therapy with cytostatic drugs in combination with NaNO₃ and hydroxamic acids

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• 作者：T. N. Bogatyrenko ; Z. V. Kuropteva ; L. M. Bayder…
• 关键词：Key wordsascorbic acid ; cyclophosphamide ; cisplatin ; nitric oxide ; hydroxamic acids ; lymphocytic leukemia ; cytochrome P450
• 刊名：Russian Chemical Bulletin
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：65
• 期：2
• 页码：561-565
• 全文大小：147 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Chemistry
  Organic Chemistry
  Inorganic Chemistry
  Russian Library of Science
  
• 出版者：Springer New York
• ISSN：1573-9171
• 卷排序：65

文摘

The present investigation is based on the paradoxical dichotomy of the biological action of nitric oxide (NO). Depending on its concentration in the organism, it can have therapeutic or pathogenic effect. It was shown that during the treatment with cisplatin (cPt) or cyclophospamide (CP), adjunct therapy with ascorbic acid (AA) known to increase the NO content in the organism extended the average lifespan (ALS) by 20—30% as compared to cytostatic monotherapy. Combination of cytostatics with sodium nitrate extended ALS by 20—38% depending on the concentration of the nitrate. The efficiency of cytotoxic therapy in combination with two chemo sensitizers (NaNO₃ and hydroxamic acid) also depends on the concentration of injected NaNO₃. Addition of AA to these combinations extended ALS by 16%, or inhibited it by 40%. Variation of the dose of injected NaNO₃ that is a NO donor in combination with endogenous NO stimulated with AA controls the action of cytostatics and combinations thereof.