Hydroxamic acids: synthesis and adjuvant activity in combinatorial anticancer therapy

详细信息    查看全文

• 作者：B. S. Fedorov ; M. A. Fadeev ; A. B. Eremeev ; N. P. Konovalova…
• 关键词：Key wordshydroxamic acids ; reaction of maleic anhydride with hydroxylamine ; antimetastatic and anticancer activity ; chemotherapy of cancer
• 刊名：Russian Chemical Bulletin
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：65
• 期：3
• 页码：801-805
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry/Food Science, general; Organic Chemistry; Inorganic Chemistry;
• 出版者：Springer US
• ISSN：1573-9171
• 卷排序：65

文摘

Monoand disubstituted N-hydroxyamides of dicarboxylic acids were prepared by reaction of dicarboxylic acids or acid anhydrides with hydroxylamine. The use of these compounds in combinatorial cytostatic therapy of implanted tumors with cisplatin or cyclophosphamide totally inhibits metastasis formation in B16 melanoma and Lewis lung carcinoma, and resulted in 100% survival of leukemic animals.