The effect of hydroxyapatite particle size on viscoelastic properties and calcium release from a thermosensitive triblock copolymer
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- 作者：I. Chamradová ; L. Vojtová ; K. Částková ; P. Diviš ; M. Peterek…
- 关键词：Polymer composites ; Smart polymers ; Rheology ; Hydroxyapatite ; Core ; shell particles ; Sol ; gel transition
- 刊名：Colloid and Polymer Science
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：295
- 期：1
- 页码：107-115
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Polymer Sciences; Soft and Granular Matter, Complex Fluids and Microfluidics; Characterization and Evaluation of Materials; Physical Chemistry; Food Science; Nanotechnology and Microengineering;
- 出版者：Springer Berlin Heidelberg
- ISSN：1435-1536
- 卷排序：295
文摘
Well-defined “smart” injectable hydrogel based on hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(lactic acid-co-glycolic acid) (PLA/PGA) copolymer (PLGA-PEG-PLGA) gelling at the body temperature was modified by bioactive hydroxyapatite (HAp) in the form of micro-, nano-, and core-shell particles (μ-HAp, n-HAp, and CS-x, respectively) to be applicable as calcium delivery system in bone regeneration. Viscoelastic moduli increased with HAp content as expected. Whereas systems containing μ-HAp or CS-x particles maintained two sol-gel and gel-sol phase transitions, the n-HAp containing system showed only one sol-gel phase transition due to the strong interactions between polymer chain and the n-HAp surface. In vitro, studies proved the controlled uniform release of calcium cations from both CS-x and n-HAp over the 9-day period without any initial burst release.