Hydroxyapatite–alendronate composite systems for biocompatible materials
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- 作者：Johny Neamtu ; Maria Viorica Bubulica…
- 关键词：Ceramics ; Microporous materials ; Chemical synthesis ; Thermogravimetric analysis ; X ; ray diffraction
- 刊名：Journal of Thermal Analysis and Calorimetry
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：127
- 期：2
- 页码：1567-1582
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Physical Chemistry; Analytical Chemistry; Polymer Sciences; Inorganic Chemistry; Measurement Science and Instrumentation;
- 出版者：Springer Netherlands
- ISSN：1588-2926
- 卷排序：127
文摘
In this study, hydroxyapatite–alendronate composites were synthesized from calcium nitrate, diammonium hydrogen phosphate and alendronate by chemical precipitation method. The obtained materials were analysed by physical–chemical methods, while the compositional and structural characteristics of hydroxyapatite–alendronate phases were determined by a combination of crystallographic, spectroscopic and thermal analysis investigations; moreover, the alendronate content, its maximal incorporation efficiency to hydroxyapatite and stability were determined. A two-level full factorial design was chosen to determine the optimum set of process parameters (synthesis temperature, reactant addition rate and ripening time) and their effects on various hydroxyapatite–alendronate characteristics: alendronate incorporation efficiency, hydroxyapatite crystallite size (XRD), hydroxyapatite particle size distribution (DLS). These effects were quantified using design of experiments. The in vitro release profile of alendronate from hydroxyapatite–alendronate tablets was assessed.