Intracellular trafficking and cellular uptake mechanism of PHBV nanoparticles for targeted delivery in epithelial cell lines

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• 作者：Juan P. Peñaloza ; Valeria Márquez-Miranda…
• 刊名：Journal of Nanobiotechnology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：2090KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Biotechnology; Nanotechnology; Molecular Medicine;
• 出版者：BioMed Central
• ISSN：1477-3155
• 卷排序：15

文摘

BackgroundNanotechnology is a science that involves imaging, measurement, modeling and a manipulation of matter at the nanometric scale. One application of this technology is drug delivery systems based on nanoparticles obtained from natural or synthetic sources. An example of these systems is synthetized from poly(3-hydroxybutyrate-co-3-hydroxyvalerate), which is a biodegradable, biocompatible and a low production cost polymer. The aim of this work was to investigate the uptake mechanism of PHBV nanoparticles in two different epithelial cell lines (HeLa and SKOV-3).