Influence of preparations containing phytoecdysteroids and plant steroid glycosides on the life span and stress resistance of Drosophila melanogaster

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• 作者：M. V. Shaposhnikov ; L. A. Shilova…
• 关键词：ecdysteroids ; steroid glycosides ; plant adaptogens ; life span ; stress resistance ; hormesis ; Drosophila
• 刊名：Russian Journal of Genetics: Applied Research
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：6
• 期：2
• 页码：215-224
• 全文大小：1,033 KB
• 参考文献：RCoreTeam. R: A Language and Environment for Statistical Computing. http://​www.​R-project.​org.​ Cited August 4, 2014.
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• 作者单位：M. V. Shaposhnikov (1) (2)
  L. A. Shilova (1)
  E. N. Plyusnina (1) (2)
  S. O. Volodina (1)
  V. V. Volodin (1)
  A. A. Moskalev (1) (2) (3)
  
  1. Institute of Biology, Komi Science Center, Ural Branch, Russian Academy of Sciences, ul. Kommunisticheskaya 28, Syktyvkar, 167982, Russia
  2. Syktyvkar State University, Syktyvkar, Russia
  3. Moscow Institute of Physics and Technology State University, Dolgoprudny, Moscow oblast, Russia
  
• 刊物主题：Human Genetics;
• 出版者：Springer US
• ISSN：2079-0600

文摘

The clarification of the molecular mechanisms of the effect of a plant adaptogen’s active substance is a topical study direction. In the present work, we studied the effect of phytopreparations containing the Serratula coronata L. phytoecdysteroids (20-hydroxyecdysone and inocosterone) or the Trigonella foenumgraecum L. steroid glycosides (dioscin and protodioscin) on the expression of stress-response genes, stress resistance, and the life span of the Drosophila melanogaster. It was demonstrated that phytopreparations activate the mechanisms of antioxidant protection (Sod1), but reduce the level of induction of DNA repair (XPF and Rad51) and the apoptosis (Hid) genes. At the same time, the studied phytopreparations have a moderate adaptogenic and geroprotective effects associated with activation of the hormesis mechanisms.